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In Vitro Fertilization and Preterm Delivery, Low Birth Weight, and Admission to the Neonatal Intensive Care Unit: a Prospective Follow-up Study

Overview
Journal Fertil Steril
Date 2010 Mar 2
PMID 20188361
Citations 38
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Abstract

Objective: To compare the risk of preterm delivery, low birth weight, and admission of the newborn to a neonatal intensive care unit (NICU) in women pregnant after fertility treatment and subfertile women with the risk in fertile women.

Design: Prospective follow-up study.

Setting: Aarhus University Hospital, Skejby, Denmark, 1989-2006.

Patient(s): A total of 20,080 liveborn singletons.

Intervention(s): None.

Main Outcome Measure(s): Preterm delivery, low birth weight, and admission of the newborn to a NICU.

Result(s): After adjustment we found a statistically significantly increased risk of preterm delivery and very preterm delivery in women who conceived after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) compared with fertile women. Compared with fertile women, the risk of preterm delivery and very preterm delivery was not statistically significantly different in women pregnant after non-IVF assisted reproductive treatment (non-IVF ART) or subfertile women. We found no association between IVF/ICSI and the risk of low birth weight at term or admittance to the NICU.

Conclusion(s): The increased risk of preterm delivery after IVF/ICSI may be due to the fertility treatment or unknown characteristics in the couples who undergo IVF/ICSI.

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