Cancer As a Reprogramming-like Disease: Implications in Tumor Development and Treatment

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2010 Mar 2

PMID 20188174

Citations 16

Authors

Andres Castellanos

Carolina Vicente-Duenas

Elena Campos-Sanchez

Juan Jesus Cruz

Francisco Javier Garcia-Criado

Maria Begona Garcia-Cenador

Pedro A Lazo

Jesus Perez-Losada

Isidro Sanchez-Garcia

Affiliations

Soon will be listed here.

Abstract

Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. Given the fact that human cancer is diagnosed at later stages and cannot be monitored during its natural evolution, the origin of tumors has been a subject of continuing discussion. Animal models provide a means to determine the identity of the cell-of-origin leading to malignancy and to develop new treatments. Recent findings in mice have shown that cancer stem cells could arise through a reprogramming-like mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of carcinogenesis and proposes research avenues for tackling these issues in the future.

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