The Role of Parkin in Familial and Sporadic Parkinson's Disease

Overview

Journal Mov Disord

Date 2010 Feb 27

PMID 20187240

Citations 179

Authors

Ted M Dawson

Valina L Dawson

Affiliations

Soon will be listed here.

Abstract

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD.

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