Endothelial Dysfunction in Diabetes Mellitus: Molecular Mechanisms and Clinical Implications

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2010 Feb 27

PMID 20186491

Citations 237

Authors

Corey E Tabit

William B Chung

Naomi M Hamburg

Joseph A Vita

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.

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