Protein-DNA and Protein-hormone Interactions in Prealbumin: a Model of the Thyroid Hormone Nuclear Receptor?

Overview

Journal Nature

Specialty Science

Date 1977 Jul 14

PMID 201845

Citations 33

Authors

C C Blake

S J Oatley

Affiliations

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Abstract

High resolution X-ray analysis of the hormone-binding protein prealbumin has shown that it has a structural complementarity to double-helical DNA. The proposed binding site is composed of two symmetry-related beta-sheets containing a pair of helically disposed arms, which can interact with the bases in the wide groove of DNA. A palindromic target sequence is indicated by the symmetry of the protein. The two identical thyroid hormone binding sites on prealbumin are located in a channel that runs completely through the molecule. These two structural features suggest prealbumin as a model for the thyroid hormone nuclear receptor, providing a number of detailed predictions of its properties.

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