Tumor Suppression by P53: Making Cells Senescent

Overview

Journal Histol Histopathol

Specialties Anatomy & Histology
Pathology

Date 2010 Feb 26

PMID 20183804

Citations 45

Authors

Yingjuan Qian

Xinbin Chen

Affiliations

Soon will be listed here.

Abstract

Cellular senescence is a permanent cell cycle arrest and a potent tumor suppression mechanism. The p53 tumor suppressor is a sequence-specific transcription factor and acts as a central hub sensing various stress signals and activating an array of target genes to induce cell cycle arrest, apoptosis, and senescence. Recent reports showed that restoration of p53 induces premature senescence and tumor regression in mice with hepatocarcinomas or sarcomas. Thus, p53-mediated senescence is capable of eliminating cancer cells in vivo. p63 and p73, two homologues of p53, have similar function in cell cycle arrest and apoptosis. However, the role of p63 and p73 in cellular senescence is elusive. In this review, we will discuss how p53 regulates senescence and future studies about p53 family members in senescence.

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