Quantitative Trait Locus Analysis of Ovarian Cysts Derived from Rete Ovarii in MRL/MpJ Mice

Overview

Journal Mamm Genome

Specialty Genetics

Date 2010 Feb 26

PMID 20182879

Citations 4

Authors

Shin-Hyo Lee

Osamu Ichii

Saori Otsuka

Yoshiharu Hashimoto

Yasuhiro Kon

Affiliations

Soon will be listed here.

Abstract

MRL/MpJ (MRL) is a model mouse for autoimmune diseases such as dermatitis, vasculitis, arthritis, and glomerulonephritis. In addition to these immune-associated disorders, we found that older MRL mice develop ovarian cysts originating from the rete ovarii, which is lined by ciliated or nonciliated epithelium and considered remnants of mesonephric tubules. Ovarian cysts, which are reported to have several sources, are associated with female infertility, but information regarding the genetic etiology of ovarian cysts originating from the rete ovarii is rare. In this study, to elucidate the genetic background of development of ovarian cysts, we performed quantitative trait locus (QTL) analysis using 120 microsatellite markers, which cover the whole genome of murine chromosomes, and 213 backcross progenies between female MRL and male C57BL/6N mice. The quantitative trait measured was the circumferences of rete ovarii or ovarian cysts. As a result, suggestive linkages were detected on Chrs 3, 4, 6, and 11, but significant linkages were located on Chr 14 by interval mapping. We thereby designated the 27.5-cM region of Chr 14 "MRL Rete Ovarian Cysts (mroc)." The peak regions of Chrs 4 and 14 in particular showed a close additive interaction (p < 0.00001). From these results we concluded that multiple loci on Chrs 3, 4, 6, 11, and 14 interact to result in development of ovarian cysts in MRL mice.

Citing Articles

Genomic analysis of the appearance of ovarian mast cells in neonatal MRL/MpJ mice.

Nakamura T, Sakata Y, Otsuka-Kanazawa S, Ichii O, Chihara M, Nagasaki K PLoS One. 2014; 9(6):e100617.

PMID: 24956472 PMC: 4067331. DOI: 10.1371/journal.pone.0100617.

Relationship between numerous mast cells and early follicular development in neonatal MRL/MpJ mouse ovaries.

Nakamura T, Otsuka S, Ichii O, Sakata Y, Nagasaki K, Hashimoto Y PLoS One. 2013; 8(10):e77246.

PMID: 24124609 PMC: 3790711. DOI: 10.1371/journal.pone.0077246.

microRNA biomarkers in cystic diseases.

Woo Y, Park J BMB Rep. 2013; 46(7):338-45.

PMID: 23884099 PMC: 4133917. DOI: 10.5483/bmbrep.2013.46.7.151.

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study.

Lee S, Ichii O, Otsuka S, Elewa Y, Yaser Hosney E, Namiki Y J Anat. 2011; 219(6):743-55.

PMID: 21951275 PMC: 3237882. DOI: 10.1111/j.1469-7580.2011.01431.x.

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