Progress and Promise Towards Safe Induced Pluripotent Stem Cells for Therapy

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2010 Feb 25

PMID 20180049

Citations 31

Authors

Ali Seifinejad

Mohammadsharif Tabebordbar

Hossein Baharvand

Laurie A Boyer

Ghasem Hosseini Salekdeh

Affiliations

Soon will be listed here.

Abstract

The recent generation of induced pluripotent stem cells (iPSCs) from somatic cells provides an invaluable resource for drug or toxicology screening, medical research, and patient-specific cell therapy. However, there are currently a number of obstacles including virus integration and the genetic alteration of iPSCs that will need to be overcome before these cells may be considered safe for clinical applications. Here, we highlight the potential and challenges of iPSC research and review advances in reprogramming methods that have rapidly moved the field closer to realizing the goal of generating safe iPSCs for transplantation.

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