Inhibitory Effects of Devil's Claw (secondary Root of Harpagophytum Procumbens) Extract and Harpagoside on Cytokine Production in Mouse Macrophages

Overview

Journal J Nat Med

Publisher Springer

Date 2010 Feb 24

PMID 20177800

Citations 16

Authors

Kazunori Inaba

Kazuya Murata

Shunsuke Naruto

Hideaki Matsuda

Affiliations

Soon will be listed here.

Abstract

Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of inflammatory cytokines [interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] in mouse macrophage cells (RAW 264.7). Harpagoside, a major iridoid glycoside present in devil's claw, was found to be one of the active agents in HP-ext and inhibited the production of IL-1beta, IL-6, and TNF-alpha by RAW 264.7.

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