Input-specific Synaptic Plasticity in the Amygdala is Regulated by Neuroligin-1 Via Postsynaptic NMDA Receptors

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2010 Feb 24

PMID 20176955

Citations 48

Authors

Sang-Yong Jung

Juhyun Kim

Oh Bin Kwon

Jung Hoon Jung

Kyongman An

A Young Jeong

C Justin Lee

Yun-Beom Choi

Craig H Bailey

Eric R Kandel

Joung-Hun Kim

Affiliations

Soon will be listed here.

Abstract

Despite considerable evidence for a critical role of neuroligin-1 in the specification of excitatory synapses, the cellular mechanisms and physiological roles of neuroligin-1 in mature neural circuits are poorly understood. In mutant mice deficient in neuroligin-1, or adult rats in which neuroligin-1 was depleted, we have found that neuroligin-1 stabilizes the NMDA receptors residing in the postsynaptic membrane of amygdala principal neurons, which allows for a normal range of NMDA receptor-mediated synaptic transmission. We observed marked decreases in NMDA receptor-mediated synaptic currents at afferent inputs to the amygdala of neuroligin-1 knockout mice. However, the knockout mice exhibited a significant impairment in spike-timing-dependent long-term potentiation (STD-LTP) at the thalamic but not the cortical inputs to the amygdala. Subsequent electrophysiological analyses indicated that STD-LTP in the cortical pathway is largely independent of activation of postsynaptic NMDA receptors. These findings suggest that neuroligin-1 can modulate, in a pathway-specific manner, synaptic plasticity in the amygdala circuits of adult animals, likely by regulating the abundance of postsynaptic NMDA receptors.

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