Mitochondria As a Target in Treatment

Overview

Journal Environ Mol Mutagen

Specialties Environmental Health
Molecular Biology

Date 2010 Feb 23

PMID 20175113

Citations 48

Authors

Marie-Celine Frantz

Peter Wipf

Affiliations

Soon will be listed here.

Abstract

Mitochondria are key organelles that perform essential cellular functions and play pivotal roles in cell death and survival signaling. Hence, they represent an attractive target for drugs to treat metabolic, degenerative, and hyperproliferative diseases. Targeting mitochondria with organelle-specific agents or prodrugs has proven to be an effective therapeutic strategy. More specifically, controlling the cellular ROS balance via selective delivery of an antioxidant "payload" into mitochondria is an elegant emerging therapeutic concept. Herein, we review the recent medicinal chemistry and clinical data of these exploratory strategies, which should point the way for future generations of therapeutics.

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