Renal Infiltration of Immunocompetent Cells: Cause and Effect of Sodium-sensitive Hypertension

Overview

Journal Clin Exp Nephrol

Publisher Springer

Specialty Nephrology

Date 2010 Feb 20

PMID 20169462

Citations 11

Authors

Bernardo Rodriguez-Iturbe

Affiliations

Soon will be listed here.

Abstract

This review examines the participation of immunocompetent cells that accumulate in tubulointerstitial areas of the kidney in the pathogenesis of sodium-sensitive hypertension. Tubulointerstitial inflammation is a universal feature in experimental models of sodium-sensitive hypertension, and the suppression of inflammation and its constant companions, oxidative stress and renal angiotensin II activity, ameliorates or prevents hypertension. Human studies also support the association between renal inflammation and hypertension. The proinflammatory effects of a high sodium diet and the mechanisms by which renal inflammation induces sodium retention are discussed. It is suggested that autoimmune reactivity may play a role in the development and maintenance of renal inflammation in hypertensive states.

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References

Weinberger M, Fineberg N . Sodium and volume sensitivity of blood pressure. Age and pressure change over time. Hypertension. 1991; 18(1):67-71. DOI: 10.1161/01.hyp.18.1.67. View

Cowley Jr A . Renal medullary oxidative stress, pressure-natriuresis, and hypertension. Hypertension. 2008; 52(5):777-86. PMC: 2659638. DOI: 10.1161/HYPERTENSIONAHA.107.092858. View

Franco M, Martinez F, Quiroz Y, Galicia O, Bautista R, Johnson R . Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol. 2007; 293(1):R251-6. DOI: 10.1152/ajpregu.00645.2006. View

Zewde T, Wu F, Mattson D . Influence of dietary NaCl on L-arginine transport in the renal medulla. Am J Physiol Regul Integr Comp Physiol. 2003; 286(1):R89-93. DOI: 10.1152/ajpregu.00309.2003. View

Romero F, Rodriguez-Iturbe B, Parra G, Gonzalez L, Herrera-Acosta J, Tapia E . Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats. Kidney Int. 1999; 55(3):945-55. DOI: 10.1046/j.1523-1755.1999.055003945.x. View

Hay J . A British Medical Association Lecture on THE SIGNIFICANCE OF A RAISED BLOOD PRESSURE. Br Med J. 2010; 2(3679):43-7. PMC: 2314188. DOI: 10.1136/bmj.2.3679.43. View

Sullivan J . Salt sensitivity. Definition, conception, methodology, and long-term issues. Hypertension. 1991; 17(1 Suppl):I61-8. DOI: 10.1161/01.hyp.17.1_suppl.i61. View

Parra G, Quiroz Y, Salazar J, Bravo Y, Pons H, Chavez M . Experimental induction of salt-sensitive hypertension is associated with lymphocyte proliferative response to HSP70. Kidney Int Suppl. 2008; (111):S55-9. DOI: 10.1038/ki.2008.513. View

Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera-Acosta J . Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol. 2002; 282(2):F191-201. DOI: 10.1152/ajprenal.0197.2001. View

10.

Johnson R, Feig D, Nakagawa T, Sanchez-Lozada L, Rodriguez-Iturbe B . Pathogenesis of essential hypertension: historical paradigms and modern insights. J Hypertens. 2008; 26(3):381-91. PMC: 2742362. DOI: 10.1097/HJH.0b013e3282f29876. View

11.

van Eden W, Koets A, van Kooten P, Prakken B, van der Zee R . Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity. Vaccine. 2003; 21(9-10):897-901. DOI: 10.1016/s0264-410x(02)00538-8. View

12.

Kitiyakara C, Chabrashvili T, Chen Y, Blau J, Karber A, Aslam S . Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol. 2003; 14(11):2775-82. DOI: 10.1097/01.asn.0000092145.90389.65. View

13.

Stewart T, Jung F, Manning J, Vehaskari V . Kidney immune cell infiltration and oxidative stress contribute to prenatally programmed hypertension. Kidney Int. 2005; 68(5):2180-8. DOI: 10.1111/j.1523-1755.2005.00674.x. View

14.

Herrera J, Ferrebuz A, MacGregor E, Rodriguez-Iturbe B . Mycophenolate mofetil treatment improves hypertension in patients with psoriasis and rheumatoid arthritis. J Am Soc Nephrol. 2006; 17(12 Suppl 3):S218-25. DOI: 10.1681/ASN.2006080918. View

15.

Mattson D, James L, Berdan E, Meister C . Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension. 2006; 48(1):149-56. DOI: 10.1161/01.HYP.0000228320.23697.29. View

16.

Rodriguez-Iturbe B, Ferrebuz A, Vanegas V, Quiroz Y, Mezzano S, Vaziri N . Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats. J Pharmacol Exp Ther. 2005; 315(1):51-7. DOI: 10.1124/jpet.105.088062. View

17.

Remuzzi G, Zoja C, Gagliardini E, Corna D, Abbate M, Benigni A . Combining an antiproteinuric approach with mycophenolate mofetil fully suppresses progressive nephropathy of experimental animals. J Am Soc Nephrol. 1999; 10(7):1542-9. DOI: 10.1681/ASN.V1071542. View

18.

Sanders P . Salt intake, endothelial cell signaling, and progression of kidney disease. Hypertension. 2004; 43(2):142-6. DOI: 10.1161/01.HYP.0000114022.20424.22. View

19.

Rodriguez-Iturbe B . [The role of immunocompetent cell renal infiltration in the pathogenesis of arterial hypertension]. Nefrologia. 2008; 28(5):483-92. View

20.

Makino A, Skelton M, Zou A, Roman R, Cowley Jr A . Increased renal medullary oxidative stress produces hypertension. Hypertension. 2002; 39(2 Pt 2):667-72. DOI: 10.1161/hy0202.103469. View