Non-caspase Proteases: Triggers or Amplifiers of Apoptosis?

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2010 Feb 20

PMID 20169397

Citations 14

Authors

Karen Schrader

Jisen Huai

Lars Jockel

Carolin Oberle

Christoph Borner

Affiliations

Soon will be listed here.

Abstract

Caspases are the most important effectors of apoptosis, the major form of programmed cell death (PCD) in multicellular organisms. This is best reflected by the appearance of serious development defects in mice deficient for caspase-8, -9, and -3. Meanwhile, caspase-independent PCD, mediated by other proteases or signaling components has been described in numerous publications. Although we do not doubt that such cell death exists, we propose that it has evolved later during evolution and is most likely not designed to execute, but to amplify and speed-up caspase-dependent cell death. This review shall provide evidence for such a concept.

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