Peroxisome Proliferator-activated Receptor (PPAR): Balance for Survival in Parasitic Infections

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2010 Feb 20

PMID 20169106

Citations 12

Authors

Marion M Chan

Kyle W Evans

Andrea R Moore

Dunne Fong

Affiliations

Soon will be listed here.

Abstract

Parasitic infections induce a magnitude of host responses. At the opposite ends of the spectrum are those that ensure the host's needs to eliminate the invaders and to minimize damage to its own tissues. This review analyzes how parasites would manipulate immunity by activating the immunosuppressive nuclear factor, peroxisome proliferator-activated receptors (PPARs) with type 2 cytokines and free fatty acids from arachidonic acid metabolism. PPARs limit the action of type 1 immunity, in which classically activated macrophages act through the production of proinflammatory signals, to spare the parasites. They also favor the development of alternately activated macrophages which control inflammation so the host would not be destroyed. Possibly, the nuclear factors hold a pivotal role in the establishment of chronic infection by delicately balancing the pro- and anti-inflammatory signaling mechanisms and their ligands may be used as combination therapeutics to limit host pathology.

Citing Articles

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