Influence of Salvia Miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2010 Feb 20

PMID 20169004

Citations 2

Authors

Zhang Xiping

Zhang Jie

Ye Shuyun

Wang Qili

Feng Guanghua

Pan Yan

Affiliations

Soon will be listed here.

Abstract

Objective: To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats.

Methods: A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.

Results: The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.

Conclusion: Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

Citing Articles

EFFECTS OF SALVIA MILTIORRHIZAE ON THE KIDNEY OF RATS WITH SEVERE ACUTE PANCREATITIS AND OBSTRUTIVE JAUNDICE.

Guibing R, Xiping Z, Xiaowen D, Dehong Z, Hongjiang Y, Xiaoru M Afr J Tradit Complement Altern Med. 2017; 14(2):103-124.

PMID: 28573227 PMC: 5446434. DOI: 10.21010/ajtcam.v14i2.12.

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects.

Hong M, Li S, Tan H, Wang N, Tsao S, Feng Y Int J Mol Sci. 2015; 16(12):28705-45.

PMID: 26633388 PMC: 4691073. DOI: 10.3390/ijms161226126.

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