New-onset Diabetes Mellitus After Kidney Transplantation in Denmark

Overview

Journal Clin J Am Soc Nephrol

Specialty Nephrology

Date 2010 Feb 20

PMID 20167685

Citations 21

Authors

Mads Hornum

Kaj Anker Jorgensen

Jesper Melchior Hansen

Finn Thomsen Nielsen

Karl Bang Christensen

Elisabeth R Mathiesen

Bo Feldt-Rasmussen

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in a prospective study of 97 nondiabetic uremic patients.

Design, Setting, Participants, & Measurements: Included were 57 kidney recipients (Tx group, age 39 +/- 13 years) and 40 uremic patients remaining on the waiting list for kidney transplantation (uremic controls, age 47 +/- 11 years). All were examined at baseline before possible transplantation and after 12 months. The prevalence of diabetes, prediabetes, insulin sensitivity index (ISI), and insulin secretion index (Isecr) were estimated using an oral glucose tolerance test with measurements of plasma glucose and plasma insulin.

Results: One year after transplantation NODM was present in 14% (8 of 57) compared with 5% (2 of 40) in the uremic control group (P = 0.01). ISI in the Tx group deteriorated from 6.8 +/- 3.9 before transplantation to 4.9 +/- 2.8 at 12 months after transplantation (P = 0.005), and a slight increase in Isecr from 37 +/- 19 to 46 +/- 22 (P = 0.02) was seen. No significant changes occurred in the uremic controls (ISI was 7.9 +/- 5 and 8.5 +/- 5, and Isecr was 31 +/- 17 and 28 +/- 15). Using multivariate ordinal logistic regression, pre-Tx ISI and age predicted NODM (odds ratios: 0.82, P = 0.01 and 1.06, P = 0.02, respectively).

Conclusions: One year after kidney transplantation, NODM was present in 14% of patients. This was mainly caused by an increase in insulin resistance and was observed despite improvement in insulin secretion.

Citing Articles

Exercise and Prediabetes After Renal Transplantation (EXPRED-I): A Prospective Study.

Febles R, Miranda D, Jimenez Sosa A, Gonzalez Rinne A, Cruz Perera C, Rodriguez-Rodriguez A Sports Med Open. 2023; 9(1):32.

PMID: 37202497 PMC: 10195924. DOI: 10.1186/s40798-023-00574-8.

Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort.

Dos Santos Q, Hornum M, Terrones-Campos C, Crone C, Wareham N, Soeborg A Transpl Int. 2022; 35:10352.

PMID: 35449717 PMC: 9016119. DOI: 10.3389/ti.2022.10352.

The Utility of Pre- and Post-Transplant Oral Glucose Tolerance Tests: Identifying Kidney Transplant Recipients With or at Risk of New Onset Diabetes After Transplant.

Singer J, Aouad L, Wyburn K, Gracey D, Ying T, Chadban S Transpl Int. 2022; 35:10078.

PMID: 35368638 PMC: 8967957. DOI: 10.3389/ti.2022.10078.

Diabetes in Kidney Transplantation.

Martinez Cantarin M Adv Chronic Kidney Dis. 2022; 28(6):596-605.

PMID: 35367028 PMC: 8988437. DOI: 10.1053/j.ackd.2021.10.004.

Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients.

Alamdari A, Asadi G, Minoo F, Khatami M, Gatmiri S, Dashti-Khavidaki S Int J Endocrinol Metab. 2020; 18(1):e97292.

PMID: 32308698 PMC: 7138613. DOI: 10.5812/ijem.97292.

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