Role of the Adaptive Immune System in Hypertension

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2010 Feb 20

PMID 20167535

Citations 80

Authors

David G Harrison

Antony Vinh

Heinrich Lob

Meena S Madhur

Affiliations

Soon will be listed here.

Abstract

Recent studies have shown that both innate and adaptive immunity contribute to hypertension. Inflammatory cells, including macrophages and T cells accumulate in the vessel wall, particularly in the perivascular fat, and in the kidney of hypertensive animals. Mice lacking lymphocytes are resistant to the development of hypertension, and adoptive transfer of T cells restores hypertensive responses to angiotensin II and DOCA-salt challenge. Immune modulating agents have variable, but often-beneficial effects in ameliorating end-organ damage and blood pressure elevation in experimental hypertension. The mechanisms by which hypertension stimulates an immune response remain unclear, but might involve the formation of neoantigens that activate adaptive immunity. Identification of these neoantigens and understanding how they form might prove useful in the prevention and treatment of this widespread and devastating disease.

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