TGF-beta-treated Antigen Presenting Cells Suppress Collagen- Induced Arthritis Through the Promotion of Th2 Responses

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2010 Feb 19

PMID 20164680

Citations 6

Authors

Sundo Jung

Yoon-Kyung Park

Hyunji Lee

Jung Hoon Shin

Gap Ryol Lee

Se-Ho Park

Affiliations

Soon will be listed here.

Abstract

Collagen-induced arthritis (CIA) is mediated by self-reactive CD4(+) T cells that produce inflammatory cytokines. TGF-beta(2)-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this study, we investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and severity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-gamma- and IL-17-producing CD4(+) T cells and increased IL-4- and IL-5-producing CD4(+) T cells upon collagen antigen stimulation in vitro. The suppression of CIA conferred by Tol-APCs correlated with their ability to selectively induce IL-10 production. We also observed that treatment of Tol-APCs inhibited not only cellular immune responses but also humoral immune responses in the process of CIA. Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases.

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References

Wilbanks G, Mammolenti M, Streilein J . Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta. Eur J Immunol. 1992; 22(1):165-73. DOI: 10.1002/eji.1830220125. View

Van de Keere F, Tonegawa S . CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med. 1998; 188(10):1875-82. PMC: 2212404. DOI: 10.1084/jem.188.10.1875. View

DOrazio T, Niederkorn J . Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber-associated immune deviation (ACAID). Immunology. 1998; 95(1):47-55. PMC: 1364375. DOI: 10.1046/j.1365-2567.1998.00581.x. View

Baron E, Proctor R . Elicitation of peritoneal polymorphonuclear neutrophils from mice. J Immunol Methods. 1982; 49(3):305-13. DOI: 10.1016/0022-1759(82)90130-2. View

Katagiri K, Zhang-Hoover J, Mo J, Stein-Streilein J, Wayne Streilein J . Using tolerance induced via the anterior chamber of the eye to inhibit Th2-dependent pulmonary pathology. J Immunol. 2002; 169(1):84-9. DOI: 10.4049/jimmunol.169.1.84. View

Wilbanks G, Streilein J . Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties. Reg Immunol. 1992; 4(3):130-7. View

Wilbanks G, Streilein J . Studies on the induction of anterior chamber-associated immune deviation (ACAID). 1. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood. J Immunol. 1991; 146(8):2610-7. View

Menges M, Rossner S, Voigtlander C, Schindler H, Kukutsch N, Bogdan C . Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J Exp Med. 2002; 195(1):15-21. PMC: 2196016. DOI: 10.1084/jem.20011341. View

Chiba A, Kaieda S, Oki S, Yamamura T, Miyake S . The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models. Arthritis Rheum. 2005; 52(6):1941-8. DOI: 10.1002/art.21056. View

10.

Mahnke K, Schmitt E, Bonifaz L, Enk A, Jonuleit H . Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol. 2002; 80(5):477-83. DOI: 10.1046/j.1440-1711.2002.01115.x. View

11.

Miossec P, van den Berg W . Th1/Th2 cytokine balance in arthritis. Arthritis Rheum. 1998; 40(12):2105-15. DOI: 10.1002/art.1780401203. View

12.

Nakae S, Nambu A, Sudo K, Iwakura Y . Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol. 2003; 171(11):6173-7. DOI: 10.4049/jimmunol.171.11.6173. View

13.

Nakajima A, Seroogy C, Sandora M, Tarner I, Costa G, Bachmann M . Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest. 2001; 107(10):1293-301. PMC: 209299. DOI: 10.1172/JCI12037. View

14.

Langrish C, Chen Y, Blumenschein W, Mattson J, Basham B, Sedgwick J . IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005; 201(2):233-40. PMC: 2212798. DOI: 10.1084/jem.20041257. View

15.

Xu Y, Kapp J . gammadelta T cells are critical for the induction of anterior chamber-associated immune deviation. Immunology. 2001; 104(2):142-8. PMC: 1783294. DOI: 10.1046/j.1365-2567.2001.01285.x. View

16.

Wilbanks G, Mammolenti M, Streilein J . Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID. J Immunol. 1991; 146(9):3018-24. View

17.

Faunce D, Terajewicz A, Stein-Streilein J . Cutting edge: in vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis. J Immunol. 2004; 172(4):1991-5. DOI: 10.4049/jimmunol.172.4.1991. View

18.

Stuart J, Dixon F . Serum transfer of collagen-induced arthritis in mice. J Exp Med. 1983; 158(2):378-92. PMC: 2187334. DOI: 10.1084/jem.158.2.378. View

19.

Zanelli E, Gonzalez-Gay M, David C . Could HLA-DRB1 be the protective locus in rheumatoid arthritis?. Immunol Today. 1995; 16(6):274-8. DOI: 10.1016/0167-5699(95)80181-2. View

20.

Courtenay J, Dallman M, Dayan A, Martin A, Mosedale B . Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980; 283(5748):666-8. DOI: 10.1038/283666a0. View