Pesticide Use and Cutaneous Melanoma in Pesticide Applicators in the Agricultural Heath Study

Overview

Journal Environ Health Perspect

Date 2010 Feb 19

PMID 20164001

Citations 43

Authors

Leslie K Dennis

Charles F Lynch

Dale P Sandler

Michael C R Alavanja

Affiliations

Soon will be listed here.

Abstract

Background: Melanoma rates continue to increase; however, few risk factors other than sun sensitivity and ultraviolet radiation (including sun exposure) have been identified. Although studies of farmers have shown an excess risk of melanoma and other skin cancers, it is unclear how much of this is related to sun exposure compared with other agricultural exposures.

Methods: We examined dose-response relationships for 50 agricultural pesticides and cutaneous melanoma incidence in the Agricultural Health Study cohort of licensed pesticide applicators, along with ever use of older pesticides that contain arsenic. Logistic regression was used to examine odds ratios (ORs) and 95% confidence intervals (CIs) associated with pesticide exposure adjusted for age, sex, and other potential confounders.

Results: We found significant associations between cutaneous melanoma and maneb/mancozeb (>or= 63 exposure days: OR = 2.4; 95% CI, 1.2-4.9; trend p = 0.006), parathion (>or= 56 exposure days: OR = 2.4; 95% CI, 1.3-4.4; trend p = 0.003), and carbaryl (>or= 56 exposure days: OR = 1.7; 95% CI, 1.1-2.5; trend p = 0.013). Other associations with benomyl and ever use of arsenical pesticides were also suggested.

Conclusions: Most previous melanoma literature has focused on host factors and sun exposure. Our research shows an association between several pesticides and melanoma, providing support for the hypotheses that agricultural chemicals may be another important source of melanoma risk.

Citing Articles

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Occupational Risk Factors for Skin Cancer: A Comprehensive Review.

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References

Wesseling C, Ahlbom A, Antich D, Rodriguez A, Castro R . Cancer in banana plantation workers in Costa Rica. Int J Epidemiol. 1996; 25(6):1125-31. DOI: 10.1093/ije/25.6.1125. View

Hsueh Y, Chiou H, Huang Y, Wu W, Huang C, Yang M . Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer. Cancer Epidemiol Biomarkers Prev. 1997; 6(8):589-96. View

Elwood J, Jopson J . Melanoma and sun exposure: an overview of published studies. Int J Cancer. 1997; 73(2):198-203. DOI: 10.1002/(sici)1097-0215(19971009)73:2<198::aid-ijc6>3.0.co;2-r. View

Brand R, Pike J, Wilson R, Charron A . Sunscreens containing physical UV blockers can increase transdermal absorption of pesticides. Toxicol Ind Health. 2004; 19(1):9-16. DOI: 10.1191/0748233703th169oa. View

Blair A, Zahm S . Cancer among farmers. Occup Med. 1991; 6(3):335-54. View

Armstrong B . Epidemiology of malignant melanoma: intermittent or total accumulated exposure to the sun?. J Dermatol Surg Oncol. 1988; 14(8):835-49. DOI: 10.1111/j.1524-4725.1988.tb03588.x. View

Shi H, Hudson L, Ding W, Wang S, Cooper K, Liu S . Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals. Chem Res Toxicol. 2004; 17(7):871-8. DOI: 10.1021/tx049939e. View

Tarone R, Alavanja M, Zahm S, Lubin J, Sandler D, McMaster S . The Agricultural Health Study: factors affecting completion and return of self-administered questionnaires in a large prospective cohort study of pesticide applicators. Am J Ind Med. 1997; 31(2):233-42. DOI: 10.1002/(sici)1097-0274(199702)31:2<233::aid-ajim13>3.0.co;2-2. View

Greene M . The genetics of hereditary melanoma and nevi. 1998 update. Cancer. 2000; 86(11 Suppl):2464-77. DOI: 10.1002/(sici)1097-0142(19991201)86:11+<2464::aid-cncr3>3.0.co;2-f. View

10.

Chen C, Chuang Y, Lin T, Wu H . Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers. Cancer Res. 1985; 45(11 Pt 2):5895-9. View

11.

Kochhar T, Howard W, Hoffman S . Effect of trivalent and pentavalent arsenic in causing chromosome alterations in cultured Chinese hamster ovary (CHO) cells. Toxicol Lett. 1996; 84(1):37-42. DOI: 10.1016/0378-4274(95)03536-2. View

12.

Pesch B, Ranft U, Jakubis P, Nieuwenhuijsen M, Hergemoller A, Unfried K . Environmental arsenic exposure from a coal-burning power plant as a potential risk factor for nonmelanoma skin carcinoma: results from a case-control study in the district of Prievidza, Slovakia. Am J Epidemiol. 2002; 155(9):798-809. DOI: 10.1093/aje/155.9.798. View

13.

An Y, Gao Z, Wang Z, Yang S, Liang J, Feng Y . Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China. Cancer Lett. 2004; 214(1):11-8. DOI: 10.1016/j.canlet.2004.04.005. View

14.

TSENG W . Effects and dose--response relationships of skin cancer and blackfoot disease with arsenic. Environ Health Perspect. 1977; 19:109-19. PMC: 1637425. DOI: 10.1289/ehp.7719109. View

15.

Purdue M, Hoppin J, Blair A, Dosemeci M, Alavanja M . Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. Int J Cancer. 2006; 120(3):642-9. PMC: 1971137. DOI: 10.1002/ijc.22258. View

16.

Crutcher W, Cohen P . Dysplastic nevi and malignant melanoma. Am Fam Physician. 1990; 42(2):372-85. View

17.

Beane Freeman L, Dennis L, Lynch C, Thorne P, Just C . Toenail arsenic content and cutaneous melanoma in Iowa. Am J Epidemiol. 2004; 160(7):679-87. DOI: 10.1093/aje/kwh267. View

18.

Huang R, Ho I, Yih L, Lee T . Sodium arsenite induces chromosome endoreduplication and inhibits protein phosphatase activity in human fibroblasts. Environ Mol Mutagen. 1995; 25(3):188-96. DOI: 10.1002/em.2850250304. View

19.

Fortes C, Mastroeni S, Melchi F, Pilla M, Alotto M, Antonelli G . The association between residential pesticide use and cutaneous melanoma. Eur J Cancer. 2007; 43(6):1066-75. DOI: 10.1016/j.ejca.2007.01.013. View

20.

Spiewak R . Pesticides as a cause of occupational skin diseases in farmers. Ann Agric Environ Med. 2001; 8(1):1-5. View