Chemokines and Chemokine Receptors: New Insights into Cancer-related Inflammation

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2010 Feb 19

PMID 20163989

Citations 342

Authors

Gwendal Lazennec

Ann Richmond

Affiliations

Soon will be listed here.

Abstract

Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation. Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted. Increasing evidence suggests that chemokines are produced by tumor cells as well as by cells of the tumor microenvironment including cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, tumor-associated macrophages (TAMs) and more recently tumor-associated neutrophils (TANs). In addition to affecting tumor cell proliferation, angiogenesis and metastasis, chemokines also seem to modulate senescence and cell survival. Here, we review recent progress on the roles of chemokines and chemokine receptors in cancer-related inflammation, and discuss the mechanisms underlying chemokine action in cancer that might facilitate the development of novel therapies in the future.

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