Developmental Hearing Loss Disrupts Synaptic Inhibition: Implications for Auditory Processing

Overview

Journal Future Neurol

Specialty Neurology

Date 2010 Feb 18

PMID 20161214

Citations 47

Authors

Anne E Takesian

Vibhakar C Kotak

Dan H Sanes

Affiliations

Soon will be listed here.

Abstract

Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspects of auditory processing. This review focuses on the anatomical and physiological alterations of inhibitory connections at several regions within the central auditory pathway following hearing loss. Such aberrant inhibitory synaptic function may be linked to deficits in encoding binaural and spectral cues. Understanding the cellular changes that occur at inhibitory synapses following hearing loss may provide specific loci that can be targeted to improve function.

Citing Articles

Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.

Kristaponyte I, Beebe N, Harish N, Schofield B, Galazyuk A Neuroscience. 2024; 566:227-238.

PMID: 39694319 PMC: 11824881. DOI: 10.1016/j.neuroscience.2024.12.021.

P1-N1-P2 Cortical Auditory Evoked Potentials in Chronic Unilateral Acquired Conductive Hearing Loss in Adults.

Dabbous A, Hosni N, Owais Emara A, El-Antably A J Int Adv Otol. 2024; 20(3):216-224.

PMID: 39128038 PMC: 11232054. DOI: 10.5152/iao.2024.231270.

Review of Binaural Processing With Asymmetrical Hearing Outcomes in Patients With Bilateral Cochlear Implants.

Anderson S, Burg E, Suveg L, Litovsky R Trends Hear. 2024; 28:23312165241229880.

PMID: 38545645 PMC: 10976506. DOI: 10.1177/23312165241229880.

Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss.

McClaskey C Hear Res. 2023; 442:108945.

PMID: 38154191 PMC: 10942735. DOI: 10.1016/j.heares.2023.108945.

Impact of Prematurity on Auditory Processing in Children.

Boboshko M, Savenko I, Garbaruk E, Knyazeva V, Vasilyeva M Pathophysiology. 2023; 30(4):505-521.

PMID: 37987307 PMC: 10661290. DOI: 10.3390/pathophysiology30040038.

References

Payne J, Rivera C, Voipio J, Kaila K . Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci. 2003; 26(4):199-206. DOI: 10.1016/S0166-2236(03)00068-7. View

Mogdans J, Knudsen E . Adaptive adjustment of unit tuning to sound localization cues in response to monaural occlusion in developing owl optic tectum. J Neurosci. 1992; 12(9):3473-84. PMC: 6575736. View

Miller G, Knudsen E . Early auditory experience induces frequency-specific, adaptive plasticity in the forebrain gaze fields of the barn owl. J Neurophysiol. 2001; 85(5):2184-94. DOI: 10.1152/jn.2001.85.5.2184. View

Gleich O, Hamann I, Klump G, Kittel M, Strutz J . Boosting GABA improves impaired auditory temporal resolution in the gerbil. Neuroreport. 2003; 14(14):1877-80. DOI: 10.1097/00001756-200310060-00024. View

Werthat F, Alexandrova O, Grothe B, Koch U . Experience-dependent refinement of the inhibitory axons projecting to the medial superior olive. Dev Neurobiol. 2008; 68(13):1454-62. DOI: 10.1002/dneu.20660. View

Wenthold R, Altschuler R, Hampson D . Immunocytochemistry of neurotransmitter receptors. J Electron Microsc Tech. 1990; 15(1):81-96. DOI: 10.1002/jemt.1060150108. View

Hogan S, Meyer S, Moore D . Binaural unmasking returns to normal in teenagers who had otitis media in infancy. Audiol Neurootol. 1996; 1(2):104-11. DOI: 10.1159/000259189. View

Turrigiano G . Homeostatic signaling: the positive side of negative feedback. Curr Opin Neurobiol. 2007; 17(3):318-24. DOI: 10.1016/j.conb.2007.04.004. View

Delpire E, Rauchman M, Beier D, Hebert S, Gullans S . Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. J Biol Chem. 1994; 269(41):25677-83. View

10.

Roberts J, Hunter L, Gravel J, Rosenfeld R, Berman S, Haggard M . Otitis media, hearing loss, and language learning: controversies and current research. J Dev Behav Pediatr. 2004; 25(2):110-22. DOI: 10.1097/00004703-200404000-00007. View

11.

Sanes D, Chokshi P . Glycinergic transmission influences the development of dendrite shape. Neuroreport. 1992; 3(4):323-6. DOI: 10.1097/00001756-199204000-00008. View

12.

Ryugo D, Kretzmer E, Niparko J . Restoration of auditory nerve synapses in cats by cochlear implants. Science. 2005; 310(5753):1490-2. DOI: 10.1126/science.1119419. View

13.

Vale C, Sanes D . The effect of bilateral deafness on excitatory and inhibitory synaptic strength in the inferior colliculus. Eur J Neurosci. 2002; 16(12):2394-404. DOI: 10.1046/j.1460-9568.2002.02302.x. View

14.

Bormann J, Hamill O, Sakmann B . Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol. 1987; 385:243-86. PMC: 1192346. DOI: 10.1113/jphysiol.1987.sp016493. View

15.

Kirkwood A, Bear M . Elementary forms of synaptic plasticity in the visual cortex. Biol Res. 1995; 28(1):73-80. View

16.

Vale C, Sanes D . Afferent regulation of inhibitory synaptic transmission in the developing auditory midbrain. J Neurosci. 2000; 20(5):1912-21. PMC: 6772929. View

17.

Franklin S, Brunso-Bechtold J, Henkel C . Bilateral cochlear ablation in postnatal rat disrupts development of banded pattern of projections from the dorsal nucleus of the lateral lemniscus to the inferior colliculus. Neuroscience. 2008; 154(1):346-54. PMC: 2474858. DOI: 10.1016/j.neuroscience.2008.02.011. View

18.

Irvine D, Rajan R . Injury-induced reorganization of frequency maps in adult auditory cortex: the role of unmasking of normally-inhibited inputs. Acta Otolaryngol Suppl. 1997; 532:39-45. DOI: 10.3109/00016489709126143. View

19.

Xu H, Kotak V, Sanes D . Conductive hearing loss disrupts synaptic and spike adaptation in developing auditory cortex. J Neurosci. 2007; 27(35):9417-26. PMC: 6673134. DOI: 10.1523/JNEUROSCI.1992-07.2007. View

20.

Dahmen J, King A . Learning to hear: plasticity of auditory cortical processing. Curr Opin Neurobiol. 2007; 17(4):456-64. DOI: 10.1016/j.conb.2007.07.004. View