Human Insulin/IGF-1 and Familial Longevity at Middle Age

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2010 Feb 17

PMID 20157552

Citations 30

Authors

Maarten P Rozing

Rudi G J Westendorp

Marijke Frolich

Anton J M de Craen

Marian Beekman

Bastiaan T Heijmans

Simon P Mooijaart

Gerard-Jan Blauw

P Eline Slagboom

Diana van Heemst

Affiliations

Soon will be listed here.

Abstract

Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

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