Growth and Aging: a Common Molecular Mechanism

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2010 Feb 17

PMID 20157523

Citations 136

Authors

Mikhail V Blagosklonny

Michael N Hall

Affiliations

Soon will be listed here.

Abstract

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

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