Is Phytalgic(R) a Goldmine for Osteoarthritis Patients or is There Something Fishy About This Nutraceutical? A Summary of Findings and Risk-of-bias Assessment

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2010 Feb 17

PMID 20156334

Citations 5

Authors

Robin Christensen

Henning Bliddal

Affiliations

Soon will be listed here.

Abstract

A food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for 3 months and according to the authors has a very large clinical effect, considerably larger than that of any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above 0.5 is rarely seen. Despite our concerns about the fact that trial registration took place after the study was completed and the likelihood that patients would note the taste of fish, a circumstance that would lead to detection bias, we consider these data promising though with a high risk of bias.

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References

Reginster J . The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest. Arthritis Rheum. 2007; 56(7):2105-10. DOI: 10.1002/art.22852. View

Vlad S, LaValley M, McAlindon T, Felson D . Glucosamine for pain in osteoarthritis: why do trial results differ?. Arthritis Rheum. 2007; 56(7):2267-77. DOI: 10.1002/art.22728. View

Jacquet A, Girodet P, Pariente A, Forest K, Mallet L, Moore N . Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther. 2009; 11(6):R192. PMC: 3003499. DOI: 10.1186/ar2891. View

Christensen R, Bartels E, Astrup A, Bliddal H . Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2007; 16(4):399-408. DOI: 10.1016/j.joca.2007.10.003. View

Christensen R, Bartels E, Altman R, Astrup A, Bliddal H . Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?--a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008; 16(9):965-72. DOI: 10.1016/j.joca.2008.03.001. View

Zhang W, Moskowitz R, Nuki G, Abramson S, Altman R, Arden N . OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage. 2007; 15(9):981-1000. DOI: 10.1016/j.joca.2007.06.014. View

Bartels E, Bliddal H, Schondorff P, Altman R, Zhang W, Christensen R . Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2009; 18(3):289-96. DOI: 10.1016/j.joca.2009.10.006. View

Nuesch E, Trelle S, Reichenbach S, Rutjes A, Burgi E, Scherer M . The effects of excluding patients from the analysis in randomised controlled trials: meta-epidemiological study. BMJ. 2009; 339:b3244. PMC: 2739282. DOI: 10.1136/bmj.b3244. View

Bliddal H, Christensen R . The treatment and prevention of knee osteoarthritis: a tool for clinical decision-making. Expert Opin Pharmacother. 2009; 10(11):1793-804. DOI: 10.1517/14656560903018911. View

10.

Nuesch E, Reichenbach S, Trelle S, Rutjes A, Liewald K, Sterchi R . The importance of allocation concealment and patient blinding in osteoarthritis trials: a meta-epidemiologic study. Arthritis Rheum. 2009; 61(12):1633-41. DOI: 10.1002/art.24894. View

11.

Bliddal H, Rosetzsky A, Schlichting P, Weidner M, Andersen L, Ibfelt H . A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage. 1999; 8(1):9-12. DOI: 10.1053/joca.1999.0264. View