Effects of 25-hydroxyvitamin D Level and Its Change on Parathyroid Hormone in Premenopausal Chinese Women

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2010 Feb 16

PMID 20155247

Citations 9

Authors

C J Bacon

J Woo

E M C Lau

C W K Lam

G D Gamble

I R Reid

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Optimal levels of 25-hydroxyvitamin D [25(OH)D] were investigated in premenopausal Chinese women. Parathyroid hormone (PTH) change at 3 months was associated with change in 25(OH)D but not with baseline levels, and PTH fell even when starting levels of 25(OH)D were >40 nmol/L, consistent with optimal values for 25(OH)D of ≥40 nmol/l.

Introduction: The upper level of 25-hydroxyvitamin D [25(OH)D] which constitutes a long-term bone health risk by causing elevated PTH levels is uncertain. Although many studies have addressed this question using cross-sectional data, the present study is one of few employing a prospective approach to determine 25(OH)D levels required to minimize PTH.

Methods: Relationships among baseline values and 3-month changes (Δ) in PTH and 25(OH)D were assessed in 221 Chinese women, aged 28.0±4.4 years (mean±SD), taking part in a placebo-controlled dairy product intervention delivering 200 IU vitamin D(3)/day.

Results: Baseline 25(OH)D was 34±11 nmol/L and was inversely related to baseline PTH (r=-0.18, P=0.007), with a plateau in PTH levels when 25(OH)D was >40 nmol/L. After 3 months intervention, PTH fell 11% and neither Δ25(OH)D nor ΔPTH differed between treatment and control groups. ΔPTH was inversely related to Δ25(OH)D (P<0.001) but not to baseline 25(OH)D. Similarly, ΔPTH differed between quartiles of Δ25(OH)D (P<0.001), but not between quartiles of baseline 25(OH)D and no interaction was observed between quartiles of baseline 25(OH)D and Δ25(OH)D. Even in the highest quartile of baseline 25(OH)D (>40 nmol/L), PTH fell 0.4±0.1 pmol/L (mean±SEM; P=0.008).

Conclusions: We conclude that vitamin D deficiency is common in young women in Hong Kong. The cross-sectional analysis indicates that optimal 25(OH)D is >40 nmol/L, and the longitudinal data is consistent with a higher optimal value which is not defined in this study's results.

Citing Articles

Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age.

Hu Y, Li S, Wang J, Zheng D, Zhang H, Yu W Int J Environ Res Public Health. 2021; 18(24).

PMID: 34948669 PMC: 8702147. DOI: 10.3390/ijerph182413060.

Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia.

Kruger M, Chan Y, Lau C, Lau L, Chin Y, Kuhn-Sherlock B Biores Open Access. 2019; 8(1):16-24.

PMID: 30842890 PMC: 6400229. DOI: 10.1089/biores.2018.0027.

Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year.

Kruger M, Chan Y, Lau L, Lau C, Chin Y, Kuhn-Sherlock B Eur J Nutr. 2017; 57(8):2785-2794.

PMID: 28975432 DOI: 10.1007/s00394-017-1544-6.

Efficacy of high dose Vitamin D supplementation in improving serum 25(OH)D among migrant and non migrant population: a retrospective study.

Gowda U, Ruwanpathirana T, Fong D, Kaur A, Renzaho A BMC Health Serv Res. 2016; 16(1):579.

PMID: 27737675 PMC: 5064956. DOI: 10.1186/s12913-016-1798-3.

Vitamin D deficiency and biochemical variations among urban Saudi adolescent girls according to season.

Sulimani R, Mohammed A, Alfadda A, Alshehri S, Al-Othman A, Al-Daghri N Saudi Med J. 2016; 37(9):1002-8.

PMID: 27570857 PMC: 5039598. DOI: 10.15537/smj.2016.9.15248.

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