The Regulation of IL-10 Production by Immune Cells

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2010 Feb 16

PMID 20154735

Citations 1383

Authors

Margarida Saraiva

Anne OGarra

Affiliations

Soon will be listed here.

Abstract

Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.

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