Vitamin E and Age-related Macular Degeneration in a Randomized Trial of Women

Overview

Journal Ophthalmology

Publisher Elsevier

Specialty Ophthalmology

Date 2010 Feb 16

PMID 20153900

Citations 11

Authors

William G Christen

Robert J Glynn

Emily Y Chew

Julie E Buring

Affiliations

Soon will be listed here.

Abstract

Objective: To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.

Design: Randomized, double-masked, placebo-controlled trial.

Participants: Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older.

Intervention: Participants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or placebo.

Main Outcome Measures: Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.

Results: After 10 years of treatment and follow-up, there were 117 cases of AMD in the vitamin E group and 128 cases in the placebo group (relative risk, 0.93; 95% confidence interval, 0.72-1.19).

Conclusions: In a large-scale randomized trial of female health professionals, long-term alternate-day use of 600 IU of natural-source vitamin E had no large beneficial or harmful effect on risk of AMD.

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Christen W, Cook N, Manson J, Buring J, Chasman D, Lee I JAMA Ophthalmol. 2020; 138(12):1280-1289.

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