Medial Prefrontal Cortex Hyperactivation During Social Exclusion in Borderline Personality Disorder

Overview

Journal Psychiatry Res

Specialty Psychiatry

Date 2010 Feb 16

PMID 20153143

Citations 29

Authors

Anthony C Ruocco

John D Medaglia

Jennifer R Tinker

Hasan Ayaz

Evan M Forman

Cory F Newman

J Michael Williams

Frank G Hillary

Steven M Platek

Banu Onaral

Douglas L Chute

Affiliations

Soon will be listed here.

Abstract

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

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