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CD4+ T Cell Plasticity-Th2 Cells Join the Crowd

Overview
Journal Immunity
Publisher Cell Press
Specialty Allergy & Immunology
Date 2010 Feb 16
PMID 20152167
Citations 22
Authors
Jinfang Zhu
William E Paul
Affiliations
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Abstract

In this issue of Immunity, Hegazy et al. (2010) report that in response to lymphocytic choriomeningitis virus (LCMV) infection, fully differentiated virus-specific Th2 cells can be reprogrammed into GATA-3(+)T-bet(+) cells capable of producing both interleukin-4 and interferon-gamma.

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Kinetics of T lymphocyte subsets and B lymphocytes in response to immunostimulants in flounder (Paralichthys olivaceus): implications for CD4 T lymphocyte differentiation.

Xing J, Tian H, Tang X, Sheng X, Zhan W Sci Rep. 2020; 10(1):13827.

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References
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Hegazy A, Peine M, Helmstetter C, Panse I, Frohlich A, Bergthaler A . Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity. 2010; 32(1):116-28. DOI: 10.1016/j.immuni.2009.12.004. View
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