Inhibition of Lipopolysaccharide-induced Nitric Oxide Production by Antofine and Its Analogues in RAW 264.7 Macrophage Cells

Overview

Journal Chem Biodivers

Specialty Biochemistry

Date 2010 Feb 13

PMID 20151387

Citations 10

Authors

Hye-Young Min

Su-Hyun Song

Boeun Lee

Sanghee Kim

Sang Kook Lee

Affiliations

Soon will be listed here.

Abstract

Based on the anti-inflammatory activity of phenanthroindolizidine alkaloids, the inhibitory effect of antofine and its analogues on lipopolysaccharide (LPS)-induced nitric oxide (NO) production was examined, and structure-activity relationships are discussed. Antofine and several analogues suppressed NO production in LPS-stimulated RAW 264.7 cells. The MeO group at C(2), and the bulkiness of the substituents at C(3) and C(6) in the phenanthrene ring might be critical for this effect. Besides, regulation of iNOS expression might be involved in the inhibitory effect of antofine on LPS-induced NO production in macrophage cells.

Citing Articles

Ethanol Extract of Inhibits Lipopolysaccharide-Induced Nitric Oxide Generation by Downregulating the Nuclear Factor-Kappa B Signaling Pathway.

Min H, Kim H, Lee H, Yoon N, Kim Y, Lee H Evid Based Complement Alternat Med. 2022; 2022:6160010.

PMID: 35722164 PMC: 9205721. DOI: 10.1155/2022/6160010.

The purification and identification of immunoregulatory peptides from oyster () enzymatic hydrolysate.

Li W, Xu C, Zhang C, Cao W, Qin X, Gao J RSC Adv. 2022; 9(56):32854-32863.

PMID: 35529727 PMC: 9073163. DOI: 10.1039/c9ra04255e.

Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids.

Jia X, Zhao H, Du C, Tang W, Wang X Phytochem Rev. 2020; 20(4):845-868.

PMID: 32994757 PMC: 7517060. DOI: 10.1007/s11101-020-09723-3.

and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications.

Chen J, Cheng C, Chen J, Lv L, Chen Z, Chen C Evid Based Complement Alternat Med. 2020; 2020:7259686.

PMID: 32774428 PMC: 7396087. DOI: 10.1155/2020/7259686.

Thymoquinone Prevents Myocardial and Perivascular Fibrosis Induced by Chronic Lipopolysaccharide Exposure in Male Rats: - Thymoquinone and Cardiac Fibrosis.

Asgharzadeh F, Bargi R, Beheshti F, Hosseini M, Farzadnia M, Khazaei M J Pharmacopuncture. 2019; 21(4):284-293.

PMID: 30652055 PMC: 6333195. DOI: 10.3831/KPI.2018.21.032.