Expression of Epiplakin1 in the Developing and Adult Mouse Retina

Overview

Journal Jpn J Ophthalmol

Specialty Ophthalmology

Date 2010 Feb 13

PMID 20151282

Citations 1

Authors

Tetsu Yoshida

Xiaoli Guo

Kazuhiko Namekata

Yoshinori Mitamura

Shoen Kume

Takayuki Harada

Affiliations

Soon will be listed here.

Abstract

Purpose: To assess the expression of Epiplakin1 (Eppk1) in the developing and adult mouse retina.

Methods: Eppk1 expression was examined using reverse transcription-polymerase chain reaction (RTPCR) analysis and immunoblot analysis. The Eppk1 expression pattern was examined by immunohistochemical analysis in embryonic and adult C57BL/6J mice.

Results: Both Eppk1 mRNA and protein were detected in adult mouse retina. Eppk1 was expressed in nestin-positive neural progenitor cells in the embryonic retina. In adults, Eppk1 was expressed in retinal ganglion cells, bipolar cells, and Müller glial cells.

Conclusions: These results suggest that Eppk1 is expressed both in embryonic and adult retina and may be involved in retinal development.

Citing Articles

Mammalian Plakins, Giant Cytolinkers: Versatile Biological Functions and Roles in Cancer.

Hu L, Huang Z, Wu Z, Ali A, Qian A Int J Mol Sci. 2018; 19(4).

PMID: 29587367 PMC: 5979291. DOI: 10.3390/ijms19040974.

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