New Insights into an Old Story: Agrobacterium-induced Tumour Formation in Plants by Plant Transformation

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2010 Feb 13

PMID 20150897

Citations 96

Authors

Andrea Pitzschke

Heribert Hirt

Affiliations

Soon will be listed here.

Abstract

Agrobacterium tumefaciens causes tumour formation in plants. Plant signals induce in the bacteria the expression of a range of virulence (Vir) proteins and the formation of a type IV secretion system (T4SS). On attachment to plant cells, a transfer DNA (T-DNA) and Vir proteins are imported into the host cells through the bacterial T4SS. Through interaction with a number of host proteins, the Vir proteins suppress the host innate immune system and support the transfer, nuclear targeting, and integration of T-DNA into host cell chromosomes. Owing to extensive genetic analyses, the bacterial side of the plant-Agrobacterium interaction is well understood. However, progress on the plant side has only been achieved recently, revealing a highly complex molecular choreography under the direction of the Vir proteins that impinge on multiple processes including transport, transcription, and chromosome status of their host cells.

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