The Primary Cilium at a Glance

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2010 Feb 11

PMID 20144997

Citations 252

Authors

Peter Satir

Lotte B Pedersen

Soren T Christensen

Affiliations

Soon will be listed here.

Citing Articles

Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia.

Jun J, Cha H, Ko J, Kim H, Yoo K, Park J Sci Rep. 2025; 15(1):2127.

PMID: 39820844 PMC: 11739504. DOI: 10.1038/s41598-025-86292-5.

The bidirectional relationship between cilia and PCP signaling pathway core protein Vangl2.

Qin H, Liang T, Zhang C, Wu J, Sheng X Sci Prog. 2025; 108(1):368504241311964.

PMID: 39819247 PMC: 11748379. DOI: 10.1177/00368504241311964.

Targeted Deletion in the Basal Body Protein Talpid3 Leads to Loss of Primary Cilia in Embryonic Stem Cells and Defective Lineage-Specific Differentiation.

Ferguson R, Subramanian V Cells. 2024; 13(23).

PMID: 39682705 PMC: 11639927. DOI: 10.3390/cells13231957.

Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus.

Hao M, Sebag S, Qian Q, Yang L eGastroenterology. 2024; 2(3).

PMID: 39512752 PMC: 11542681. DOI: 10.1136/egastro-2024-100096.

Structure, interaction and nervous connectivity of beta cell primary cilia.

Muller A, Klena N, Pang S, Garcia L, Topcheva O, Aurrecoechea Duran S Nat Commun. 2024; 15(1):9168.

PMID: 39448638 PMC: 11502866. DOI: 10.1038/s41467-024-53348-5.

References

Nauli S, Kawanabe Y, Kaminski J, Pearce W, Ingber D, Zhou J . Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation. 2008; 117(9):1161-71. PMC: 3071982. DOI: 10.1161/CIRCULATIONAHA.107.710111. View

Schneider L, Cammer M, Lehman J, Nielsen S, Guerra C, Veland I . Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem. 2010; 25(2-3):279-92. PMC: 2924811. DOI: 10.1159/000276562. View

Knight M, McGlashan S, Garcia M, Jensen C, Poole C . Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium?. J Anat. 2009; 214(2):275-83. PMC: 2667885. DOI: 10.1111/j.1469-7580.2008.01021.x. View

Fischer E, Legue E, Doyen A, Nato F, Nicolas J, Torres V . Defective planar cell polarity in polycystic kidney disease. Nat Genet. 2005; 38(1):21-3. DOI: 10.1038/ng1701. View

Christensen S, Pedersen L, Schneider L, Satir P . Sensory cilia and integration of signal transduction in human health and disease. Traffic. 2007; 8(2):97-109. DOI: 10.1111/j.1600-0854.2006.00516.x. View

Pazour G, Dickert B, Vucica Y, Seeley E, Rosenbaum J, Witman G . Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000; 151(3):709-18. PMC: 2185580. DOI: 10.1083/jcb.151.3.709. View

Handel M, Schulz S, Stanarius A, Schreff M, Schmidt H, Wolf G . Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience. 1999; 89(3):909-26. DOI: 10.1016/s0306-4522(98)00354-6. View

Sorokin S . Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J Cell Sci. 1968; 3(2):207-30. DOI: 10.1242/jcs.3.2.207. View

SOROKIN S . Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells. J Cell Biol. 1962; 15:363-77. PMC: 2106144. DOI: 10.1083/jcb.15.2.363. View

10.

AbouAlaiwi W, Takahashi M, Mell B, Jones T, Ratnam S, Kolb R . Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ Res. 2009; 104(7):860-9. PMC: 3085025. DOI: 10.1161/CIRCRESAHA.108.192765. View

11.

Bell A, Satir P, Grimes G . Mirror-imaged doublets of Tetmemena pustulata: implications for the development of left-right asymmetry. Dev Biol. 2008; 314(1):150-60. DOI: 10.1016/j.ydbio.2007.11.020. View

12.

Veland I, Awan A, Pedersen L, Yoder B, Christensen S . Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol. 2009; 111(3):p39-53. PMC: 2881330. DOI: 10.1159/000208212. View

13.

Romano S, Milan G, Veronese C, Collin G, Marshall J, Centobene C . Regulation of Alström syndrome gene expression during adipogenesis and its relationship with fat cell insulin sensitivity. Int J Mol Med. 2008; 21(6):731-6. View

14.

Kuehn E, Walz G, Benzing T . Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res. 2007; 67(10):4537-40. DOI: 10.1158/0008-5472.CAN-07-0391. View

15.

Hierck B, van der Heiden K, Alkemade F, van de Pas S, van Thienen J, Groenendijk B . Primary cilia sensitize endothelial cells for fluid shear stress. Dev Dyn. 2008; 237(3):725-35. DOI: 10.1002/dvdy.21472. View

16.

Schneider L, Stock C, Dieterich P, Jensen B, Pedersen L, Satir P . The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium. J Cell Biol. 2009; 185(1):163-76. PMC: 2700519. DOI: 10.1083/jcb.200806019. View

17.

Davenport J, Watts A, Roper V, Croyle M, van Groen T, Wyss J . Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol. 2007; 17(18):1586-94. PMC: 2084209. DOI: 10.1016/j.cub.2007.08.034. View

18.

Insinna C, Besharse J . Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors. Dev Dyn. 2008; 237(8):1982-92. PMC: 2692564. DOI: 10.1002/dvdy.21554. View

19.

Jensen C, Poole C, McGlashan S, Marko M, Issa Z, Vujcich K . Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ. Cell Biol Int. 2004; 28(2):101-10. DOI: 10.1016/j.cellbi.2003.11.007. View

20.

Wang Z, Li V, Chan G, Phan T, Nudelman A, Xia Z . Adult type 3 adenylyl cyclase-deficient mice are obese. PLoS One. 2009; 4(9):e6979. PMC: 2735775. DOI: 10.1371/journal.pone.0006979. View