Short RNAs: How Big is This Iceberg?

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2010 Feb 11

PMID 20144771

Citations 5

Authors

Isidore Rigoutsos

Affiliations

Soon will be listed here.

Abstract

Recent studies have reported the identification of piwi-associated RNAs (piRNAs) in Drosophila somatic cells. Interestingly, these piRNAs derive from the 3' untranslated regions of a subset of transcribed protein-coding genes and, experimentation suggests, might control the expression of other protein-coding transcripts. Studies of additional organisms support the new pathway's presence across animals.

Citing Articles

The transcriptional trajectories of pluripotency and differentiation comprise genes with antithetical architecture and repetitive-element content.

Telonis A, Rigoutsos I BMC Biol. 2021; 19(1):60.

PMID: 33765992 PMC: 7995781. DOI: 10.1186/s12915-020-00928-8.

tRNA Fragments Show Intertwining with mRNAs of Specific Repeat Content and Have Links to Disparities.

Telonis A, Loher P, Magee R, Pliatsika V, Londin E, Kirino Y Cancer Res. 2019; 79(12):3034-3049.

PMID: 30996049 PMC: 6571059. DOI: 10.1158/0008-5472.CAN-19-0789.

N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration.

Rigoutsos I, Lee S, Nam S, Anfossi S, Pasculli B, Pichler M Genome Biol. 2017; 18(1):98.

PMID: 28535802 PMC: 5442648. DOI: 10.1186/s13059-017-1224-0.

"Off-Spotter": very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs.

Pliatsika V, Rigoutsos I Biol Direct. 2015; 10:4.

PMID: 25630343 PMC: 4326336. DOI: 10.1186/s13062-015-0035-z.

MicroRNAs, wild-type and mutant p53: more questions than answers.

Jones M, Lal A RNA Biol. 2012; 9(6):781-91.

PMID: 22664917 PMC: 3495745. DOI: 10.4161/rna.20146.