Relevance of Helicobacter Pylori Genotypes in Gastric Pathology and Its Association with Plasma Malondialdehyde and Nitric Oxide Levels

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2010 Feb 10

PMID 20143166

Citations 7

Authors

Santosh K Tiwari

G Manoj

Vishwas Sharma

G Sivaram

R Saikant

Avinash Bardia

Varun K Sharma

Zakia Abid

Aleem A Khan

M Aejaz Habeeb

C M Habibullah

B Santhosh Kumar

Amrita Nandan

Affiliations

Soon will be listed here.

Abstract

Persistent infection with Helicobacter pylori confers an increased risk of peptic ulceration and gastric adenocarcinoma. Reactive oxygen and nitrogen species play a crucial role in the progression from normal gastric mucosa to cancer. The aim of the present study was to investigate the plasma malondialdehyde and nitric oxide levels in H. pylori related gastroduodenal diseases and associate their levels with gastric pathology and genotypes of H. pylori. Malondialdehyde and nitric oxide levels in plasma samples of 250 subjects were spectrophotometrically determined. Subsequently, genotypic and histopathological assessment was performed in gastric biopsies obtained during endoscopy. The levels of MDA and NO exceeded in subjects infected with genotype-1 of Hp than those with other genotypes suggesting more precise interaction of highly virulent strains of Hp in eliciting severe tissue damage. In conclusion, the study demonstrates close relationship between the plasma malondialdehyde and nitric oxide levels, gastric histopathology and genotypes of H. pylori.

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