Mitogen Activated Protein Kinase Phosphatases and Cancer

Overview

Journal Cancer Biol Ther

Specialties Oncology
Pharmacology

Date 2010 Feb 9

PMID 20139719

Citations 35

Authors

Kelly K Haagenson

Gen Sheng Wu

Affiliations

Soon will be listed here.

Abstract

Deregulation of cell signaling is a vital part of cancer development. The mitogen activated protein kinase (MAPK) family is involved in regulating both cell growth and cell death. This family of kinases is negatively regulated by mitogen activated protein kinase phosphatases (MKPs). MKPs are dual specificity phosphatases that target threonine and tyrosine residues that appear in a TXY motif. There are eleven members of the MKP family. Expression of MKPs has been shown to be altered in many different types of cancer. Most of what is known centers on MKP-1, MKP-2 and MKP-3. This review will focus on their role in cancer development and progression.

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References

Boutros T, Chevet E, Metrakos P . Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008; 60(3):261-310. DOI: 10.1124/pr.107.00106. View

Keyse S . Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008; 27(2):253-61. DOI: 10.1007/s10555-008-9123-1. View

Dickinson R, Keyse S . Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci. 2006; 119(Pt 22):4607-15. DOI: 10.1242/jcs.03266. View

Wang J, Zhou J, Zhang L, Wu G . Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells. Cell Cycle. 2009; 8(19):3191-8. PMC: 4063298. DOI: 10.4161/cc.8.19.9751. View

Yip-Schneider M, Lin A, Marshall M . Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. Biochem Biophys Res Commun. 2001; 280(4):992-7. DOI: 10.1006/bbrc.2001.4243. View

Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A . Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am J Pathol. 2003; 162(6):1807-15. PMC: 1868131. DOI: 10.1016/S0002-9440(10)64315-5. View

Camps M, Nichols A, Arkinstall S . Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 2000; 14(1):6-16. View

Liu Y, Shepherd E, Nelin L . MAPK phosphatases--regulating the immune response. Nat Rev Immunol. 2007; 7(3):202-12. DOI: 10.1038/nri2035. View

Denkert C, Schmitt W, Berger S, Reles A, Pest S, Siegert A . Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Int J Cancer. 2002; 102(5):507-13. DOI: 10.1002/ijc.10746. View

10.

Zhou J, Liu Y, Wu G . The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death. Cancer Res. 2006; 66(9):4888-94. DOI: 10.1158/0008-5472.CAN-05-4229. View

11.

Keyse S, GINSBURG M . Amino acid sequence similarity between CL100, a dual-specificity MAP kinase phosphatase and cdc25. Trends Biochem Sci. 1993; 18(10):377-8. DOI: 10.1016/0968-0004(93)90092-2. View

12.

Cui Y, Parra I, Zhang M, Hilsenbeck S, Tsimelzon A, Furukawa T . Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Res. 2006; 66(11):5950-9. PMC: 4484848. DOI: 10.1158/0008-5472.CAN-05-3243. View

13.

Lazo J, Skoko J, Werner S, Mitasev B, Bakan A, Koizumi F . Structurally unique inhibitors of human mitogen-activated protein kinase phosphatase-1 identified in a pyrrole carboxamide library. J Pharmacol Exp Ther. 2007; 322(3):940-7. DOI: 10.1124/jpet.107.122242. View

14.

Chan D, Liu V, Tsao G, Yao K, Furukawa T, Chan K . Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis. 2008; 29(9):1742-50. DOI: 10.1093/carcin/bgn167. View

15.

Warmka J, Mauro L, Wattenberg E . Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. J Biol Chem. 2004; 279(32):33085-92. DOI: 10.1074/jbc.M403120200. View

16.

Hoornaert I, Marynen P, Goris J, Sciot R, Baens M . MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. Oncogene. 2003; 22(49):7728-36. DOI: 10.1038/sj.onc.1207089. View

17.

Wang H, Cheng Z, Malbon C . Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Cancer Lett. 2003; 191(2):229-37. DOI: 10.1016/s0304-3835(02)00612-2. View

18.

Givant-Horwitz V, Davidson B, Goderstad J, Nesland J, Trope C, Reich R . The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma. Gynecol Oncol. 2004; 93(2):517-23. DOI: 10.1016/j.ygyno.2004.03.009. View

19.

Zaidi S, Dowdy C, van Wijnen A, Lian J, Raza A, Stein J . Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. Cancer Res. 2009; 69(21):8249-55. PMC: 2995702. DOI: 10.1158/0008-5472.CAN-09-1567. View

20.

Yokoyama A, Karasaki H, Urushibara N, Nomoto K, Imai Y, Nakamura K . The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver. Biochem Biophys Res Commun. 1997; 239(3):746-51. DOI: 10.1006/bbrc.1997.7547. View