IL-2/anti-IL-2 Antibody Complexes Show Strong Biological Activity by Avoiding Interaction with IL-2 Receptor Alpha Subunit CD25

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2010 Feb 6

PMID 20133862

Citations 108

Authors

Sven Letourneau

Ester M M van Leeuwen

Carsten Krieg

Chris Martin

Giuseppe Pantaleo

Jonathan Sprent

Charles D Surh

Onur Boyman

Affiliations

Soon will be listed here.

Abstract

IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.

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