Central Chemoreception in Wakefulness and Sleep: Evidence for a Distributed Network and a Role for Orexin

Overview

Journal J Appl Physiol (1985)

Publisher American Physiological Society

Date 2010 Feb 6

PMID 20133433

Citations 30

Authors

Eugene Nattie

Aihua Li

Affiliations

Soon will be listed here.

Abstract

This minireview examines data showing the locations of central chemoreceptor sites as identified by the presence of ventilatory responses to focal, mild acidification produced in unanesthetized animals in vivo, how the site-specific responses vary by arousal state, and what the emerging role of orexin might be in this state-dependent central chemoreceptor system. We comment on the organization of this distributed central chemoreceptor system and suggest that interactions among sites are synergistic and not additive, which is an important aspect of its normal function.

Citing Articles

Exaggerated postnatal surge of orexin neurons and the effects of elimination of excess orexin on blood pressure and exaggerated chemoreflex in spontaneously hypertensive rats.

Lusk S, Moushey A, Iwakoshi N, Wilson C, Li A, Ray R Front Physiol. 2024; 15:1341649.

PMID: 39469444 PMC: 11513569. DOI: 10.3389/fphys.2024.1341649.

Galaninergic and hypercapnia-activated neuronal projections to the ventral respiratory column.

Dereli A, Oh A, McMullan S, Kumar N Brain Struct Funct. 2024; 229(5):1121-1142.

PMID: 38578351 PMC: 11147908. DOI: 10.1007/s00429-024-02782-8.

Chronic moderate hypercapnia suppresses ventilatory responses to acute CO<sub>2</sub> challenges.

Buchholz K, Neumueller S, Burgraff N, Hodges M, Pan L, Forster H J Appl Physiol (1985). 2022; 133(5):1106-1118.

PMID: 36135953 PMC: 9621709. DOI: 10.1152/japplphysiol.00407.2022.

The O-sensitive brain stem, hyperoxic hyperventilation, and CNS oxygen toxicity.

Dean J, Stavitzski N Front Physiol. 2022; 13:921470.

PMID: 35957982 PMC: 9360621. DOI: 10.3389/fphys.2022.921470.

Influence of light/dark cycle and orexins on breathing control in green iguanas (Iguana iguana).

Fonseca E, Vicente M, Fournier S, Kinkead R, Bicego K, Gargaglioni L Sci Rep. 2020; 10(1):22105.

PMID: 33328521 PMC: 7744544. DOI: 10.1038/s41598-020-79107-2.

References

Sakurai T . Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis. CNS Neurol Disord Drug Targets. 2006; 5(3):313-25. DOI: 10.2174/187152706777452218. View

Nakamura A, Zhang W, Yanagisawa M, Fukuda Y, Kuwaki T . Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. J Appl Physiol (1985). 2006; 102(1):241-8. DOI: 10.1152/japplphysiol.00679.2006. View

Weese-Mayer D, Berry-Kravis E, Ceccherini I, Rand C . Congenital central hypoventilation syndrome (CCHS) and sudden infant death syndrome (SIDS): kindred disorders of autonomic regulation. Respir Physiol Neurobiol. 2008; 164(1-2):38-48. DOI: 10.1016/j.resp.2008.05.011. View

Severinghaus J . Hans Loeschcke, Robert Mitchell and the medullary CO2 chemoreceptors: a brief historical review. Respir Physiol. 1998; 114(1):17-24. DOI: 10.1016/s0034-5687(98)00075-9. View

Saper C, Scammell T, Lu J . Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005; 437(7063):1257-63. DOI: 10.1038/nature04284. View

Nattie E, Li A . Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat. J Appl Physiol (1985). 2006; 101(6):1596-606. DOI: 10.1152/japplphysiol.00347.2006. View

Akilesh M, Kamper M, Li A, Nattie E . Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats. J Appl Physiol (1985). 1997; 82(2):469-79. DOI: 10.1152/jappl.1997.82.2.469. View

Takakura A, Santos Moreira T, Colombari E, West G, Stornetta R, Guyenet P . Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. J Physiol. 2006; 572(Pt 2):503-23. PMC: 1779666. DOI: 10.1113/jphysiol.2005.103788. View

Li A, Zhou S, Nattie E . Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats. J Physiol. 2006; 577(Pt 1):307-18. PMC: 2000693. DOI: 10.1113/jphysiol.2006.114504. View

10.

FENCL V, Miller T, PAPPENHEIMER J . Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am J Physiol. 1966; 210(3):459-72. DOI: 10.1152/ajplegacy.1966.210.3.459. View

11.

Nattie E, Li A . CO2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol (1985). 2001; 90(4):1247-57. DOI: 10.1152/jappl.2001.90.4.1247. View

12.

Arita H, Ichikawa K, Kuwana S, Kogo N . Possible locations of pH-dependent central chemoreceptors: intramedullary regions with acidic shift of extracellular fluid pH during hypercapnia. Brain Res. 1989; 485(2):285-93. DOI: 10.1016/0006-8993(89)90572-6. View

13.

Hodges M, Martino P, Davis S, Opansky C, Pan L, Forster H . Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats. J Appl Physiol (1985). 2004; 97(6):2303-9. DOI: 10.1152/japplphysiol.00645.2004. View

14.

Ritucci N, Dean J, Putnam R . Somatic vs. dendritic responses to hypercapnia in chemosensitive locus coeruleus neurons from neonatal rats. Am J Physiol Cell Physiol. 2005; 289(5):C1094-104. PMC: 1262647. DOI: 10.1152/ajpcell.00329.2004. View

15.

Nattie E, Li A, St John W . Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats. J Appl Physiol (1985). 1991; 71(4):1364-75. DOI: 10.1152/jappl.1991.71.4.1364. View

16.

Biancardi V, Bicego K, Almeida M, Gargaglioni L . Locus coeruleus noradrenergic neurons and CO2 drive to breathing. Pflugers Arch. 2007; 455(6):1119-28. DOI: 10.1007/s00424-007-0338-8. View

17.

Deng B, Nakamura A, Zhang W, Yanagisawa M, Fukuda Y, Kuwaki T . Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice. J Appl Physiol (1985). 2007; 103(5):1772-9. DOI: 10.1152/japplphysiol.00075.2007. View

18.

Dugovic C, Shelton J, Aluisio L, Fraser I, Jiang X, Sutton S . Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J Pharmacol Exp Ther. 2009; 330(1):142-51. DOI: 10.1124/jpet.109.152009. View

19.

Nichols N, Hartzler L, Conrad S, Dean J, Putnam R . Intrinsic chemosensitivity of individual nucleus tractus solitarius (NTS) and locus coeruleus (LC) neurons from neonatal rats. Adv Exp Med Biol. 2007; 605:348-52. DOI: 10.1007/978-0-387-73693-8_61. View

20.

Nattie E, Li A . Retrotrapezoid nucleus lesions decrease phrenic activity and CO2 sensitivity in rats. Respir Physiol. 1994; 97(1):63-77. DOI: 10.1016/0034-5687(94)90012-4. View