Evolution and Phyletic Distribution of Two-component Signal Transduction Systems

Overview

Journal Curr Opin Microbiol

Specialty Microbiology

Date 2010 Feb 6

PMID 20133179

Citations 119

Authors

Kristin Wuichet

Brian J Cantwell

Igor B Zhulin

Affiliations

Soon will be listed here.

Abstract

Two-component signal transduction systems are abundant in prokaryotes. They enable cells to adjust multiple cellular functions in response to changing environmental conditions. These systems are also found, although in much smaller numbers, in lower eukaryotes and plants, where they appear to control a few very specific functions. Two-component systems have evolved in Bacteria from much simpler one-component systems bringing about the benefit of extracellular versus intracellular sensing. We review reports establishing the origins of two-component systems and documenting their occurrence in major lineages of Life.

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