Role of Platelets in Neuroinflammation: a Wide-angle Perspective

Overview

Journal J Neuroinflammation

Publisher Biomed Central

Date 2010 Feb 5

PMID 20128908

Citations 48

Authors

Lawrence L Horstman

Wenche Jy

Yeon S Ahn

Robert Zivadinov

Amir H Maghzi

Masoud Etemadifar

J Steven Alexander

Alireza Minagar

Affiliations

Soon will be listed here.

Abstract

Objectives: This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.

Organization: After a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.

Conclusion: The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research.

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