Role of Metallothionein in Differentiation of Leukemia Cells

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2010 Feb 4

PMID 20127519

Citations 5

Authors

Pegah Maghdooni Bagheri

Iris Govaerts

Marc De Ley

Affiliations

Soon will be listed here.

Abstract

Metallothioneins (MTs), a group of small, cystein-rich proteins, possess various functions, including metal detoxification and homeostasis. We here report new findings on the participation of MT in cellular differentiation processes. MT isogene transcription was significantly increased in phorbol-12-myristate-13-acetate (PMA) incubated leukemic DAMI cells, which supports its role in cellular differentiation. To further address this possibility, we constructed one stable MT-2A overexpressing DAMI cell line. Increase of cell size, intracellular granulation and megakaryocytic specific antigen expression such as CD41 and CD42, and arresting cell proliferation have validated the role of MT in differentiation in this cell line.

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