Potential of Macrostomum Lignano to Recover from Gamma-ray Irradiation

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 2010 Feb 4

PMID 20127258

Citations 13

Authors

Katrien De Mulder

Georg Kuales

Daniela Pfister

Bernhard Egger

Thomas Seppi

Paul Eichberger

Gaetan Borgonie

Peter Ladurner

Affiliations

Soon will be listed here.

Abstract

Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1 month in a dose-dependent manner following exposure to up to 150 Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210 Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems.

Citing Articles

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