Mitochondria Get a Parkin' Ticket

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2010 Feb 2

PMID 20118996

Citations 27

Authors

Philipp Wild

Ivan Dikic

Affiliations

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Abstract

Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

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