Emerging Roles of Fibronectin in Thrombosis

Overview

Journal Thromb Res

Date 2010 Feb 2

PMID 20116835

Citations 20

Authors

Lisa M Maurer

Bianca R Tomasini-Johansson

Deane F Mosher

Affiliations

Soon will be listed here.

Abstract

Fibronectin (FN) is a glycoprotein recognized originally in the 1940's as a contaminant of fibrinogen in Cohn fraction I of plasma. Decades of research demonstrated FN synthesis by a variety of cells and defined FN as an essential component of the extracellular matrix with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. We discuss the mechanisms by which this might occur and conclude that FN may have a unique role in thrombosis without affecting normal hemostasis and therefore may be a reasonable therapeutic target for the prevention of thrombotic diseases.

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