The Role of Nitric Oxide in Mycobacterial Infections

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2010 Jan 29

PMID 20107543

Citations 38

Authors

Chul-Su Yang

Jae-Min Yuk

Eun-Kyeong Jo

Affiliations

Soon will be listed here.

Abstract

Although tuberculosis poses a significant health threat to the global population, it is a challenge to develop new and effective therapeutic strategies. Nitric oxide (NO) and inducible NO synthase (iNOS) are important in innate immune responses to various intracellular bacterial infections, including mycobacterial infections. It is generally recognized that reactive nitrogen intermediates play an effective role in host defense mechanisms against tuberculosis. In a murine model of tuberculosis, NO plays a crucial role in antimycobacterial activity; however, it is controversial whether NO is critically involved in host defense against Mycobacterium tuberculosis in humans. Here, we review the roles of NO in host defense against murine and human tuberculosis. We also discuss the specific roles of NO in the central nervous system and lung epithelial cells during mycobacterial infection. A greater understanding of these defense mechanisms in human tuberculosis will aid in the development of new strategies for the treatment of disease.

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References

Rockett K, Brookes R, Udalova I, Vidal V, Hill A, Kwiatkowski D . 1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line. Infect Immun. 1998; 66(11):5314-21. PMC: 108664. DOI: 10.1128/IAI.66.11.5314-5321.1998. View

Aston C, Rom W, Talbot A, Reibman J . Early inhibition of mycobacterial growth by human alveolar macrophages is not due to nitric oxide. Am J Respir Crit Care Med. 1998; 157(6 Pt 1):1943-50. DOI: 10.1164/ajrccm.157.6.9705028. View

Tucker P, Griffin D, Choi S, Bui N, Wesselingh S . Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. J Virol. 1996; 70(6):3972-7. PMC: 190275. DOI: 10.1128/JVI.70.6.3972-3977.1996. View

Alam M, Akaike T, Okamoto S, Kubota T, Yoshitake J, Sawa T . Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun. 2002; 70(6):3130-42. PMC: 127959. DOI: 10.1128/IAI.70.6.3130-3142.2002. View

Wang C, Liu C, Lin H, Yu C, Chung K, Kuo H . Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages. Eur Respir J. 1998; 11(4):809-15. DOI: 10.1183/09031936.98.11040809. View

Adler H, Beland J, Kobzik L, Brewer J, Martin T, Rimm I . Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). J Exp Med. 1997; 185(9):1533-40. PMC: 2196291. DOI: 10.1084/jem.185.9.1533. View

Choi H, Rai P, Chu H, Cool C, Chan E . Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis. Am J Respir Crit Care Med. 2002; 166(2):178-86. DOI: 10.1164/rccm.2201023. View

Rojas M, Barrera L, Puzo G, Garcia L . Differential induction of apoptosis by virulent Mycobacterium tuberculosis in resistant and susceptible murine macrophages: role of nitric oxide and mycobacterial products. J Immunol. 1997; 159(3):1352-61. View

Rock R, Gekker G, Hu S, Sheng W, Cheeran M, Lokensgard J . Role of microglia in central nervous system infections. Clin Microbiol Rev. 2004; 17(4):942-64, table of contents. PMC: 523558. DOI: 10.1128/CMR.17.4.942-964.2004. View

10.

Sharma M, Sharma S, Roy S, Varma S, Bose M . Pulmonary epithelial cells are a source of interferon-gamma in response to Mycobacterium tuberculosis infection. Immunol Cell Biol. 2007; 85(3):229-37. DOI: 10.1038/sj.icb.7100037. View

11.

Ralph A, Kelly P, Anstey N . L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol. 2008; 16(7):336-44. DOI: 10.1016/j.tim.2008.04.003. View

12.

MacMicking J, Xie Q, Nathan C . Nitric oxide and macrophage function. Annu Rev Immunol. 1997; 15:323-50. DOI: 10.1146/annurev.immunol.15.1.323. View

13.

Adams L, Franzblau S, Vavrin Z, Hibbs Jr J, Krahenbuhl J . L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J Immunol. 1991; 147(5):1642-6. View

14.

Jagannath C, Actor J, Hunter Jr R . Induction of nitric oxide in human monocytes and monocyte cell lines by Mycobacterium tuberculosis. Nitric Oxide. 1998; 2(3):174-86. DOI: 10.1006/niox.1998.9999. View

15.

Kwon O . The role of nitric oxide in the immune response of tuberculosis. J Korean Med Sci. 1998; 12(6):481-7. PMC: 3054327. DOI: 10.3346/jkms.1997.12.6.481. View

16.

Bolovan-Fritts C, Spector S . Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction. Blood. 2007; 111(1):175-82. PMC: 2200803. DOI: 10.1182/blood-2007-08-107730. View

17.

Doi T, Ando M, Akaike T, Suga M, Sato K, Maeda H . Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis. Infect Immun. 1993; 61(5):1980-9. PMC: 280792. DOI: 10.1128/iai.61.5.1980-1989.1993. View

18.

Kwon O, Kim J, Kim H, Suh G, Park J, Chung M . Nitric oxide expression in airway epithelial cells in response to tubercle bacilli stimulation. Respirology. 1998; 3(2):119-24. DOI: 10.1111/j.1440-1843.1998.tb00109.x. View

19.

Kropf P, Baud D, Marshall S, Munder M, Mosley A, Fuentes J . Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol. 2007; 37(4):935-45. PMC: 2699382. DOI: 10.1002/eji.200636542. View

20.

Wang C, Lin H, Liu C, Huang K, Huang T, Yu C . Upregulation of inducible nitric oxide synthase and cytokine secretion in peripheral blood monocytes from pulmonary tuberculosis patients. Int J Tuberc Lung Dis. 2001; 5(3):283-91. View