Cardiac Autonomic Neuropathy in Diabetes: a Clinical Perspective

Overview

Journal Diabetes Care

Specialty Endocrinology

Date 2010 Jan 28

PMID 20103559

Citations 191

Authors

Rodica Pop-Busui

Affiliations

Soon will be listed here.

Citing Articles

Cardiac Autonomic Neuropathy in Diabetes Mellitus: Pathogenesis, Epidemiology, Diagnosis and Clinical Implications: A Narrative Review.

Gogan A, Potre O, Avram V, Andor M, Caruntu F, Timar B J Clin Med. 2025; 14(3).

PMID: 39941342 PMC: 11818907. DOI: 10.3390/jcm14030671.

Cross-cutting effect of type 2 diabetes on the sensorimotor control of balance.

Lopatin T, Borngesser B, Haworth J Front Clin Diabetes Healthc. 2025; 5():1441947.

PMID: 39845776 PMC: 11750827. DOI: 10.3389/fcdhc.2024.1441947.

Diabetes Mellitus and Cardiovascular Disease: Exploring Epidemiology, Pathophysiology, and Treatment Strategies.

Siam N, Snigdha N, Tabasumma N, Parvin I Rev Cardiovasc Med. 2025; 25(12):436.

PMID: 39742220 PMC: 11683709. DOI: 10.31083/j.rcm2512436.

Orthostatic test shows higher systolic blood pressure and sympathetic response in uncomplicated type 1 diabetes patients with normal V̇O vs. healthy controls.

Sorola S, Hyryla V, Eronen T, Kupari S, Venojarvi M, Tikkanen H Clin Auton Res. 2024; .

PMID: 39681809 DOI: 10.1007/s10286-024-01094-5.

Effects of Revascularization on Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus Patients With Chronic Stable Angina.

Alauddin W, Radke P, Pardhi P, Mishra M, Arora S Cureus. 2024; 16(10):e72278.

PMID: 39583530 PMC: 11585208. DOI: 10.7759/cureus.72278.

References

Cryer P . Hypoglycemia-associated autonomic failure in diabetes. Am J Physiol Endocrinol Metab. 2001; 281(6):E1115-21. DOI: 10.1152/ajpendo.2001.281.6.E1115. View

. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA. 2003; 290(16):2159-67. PMC: 2622725. DOI: 10.1001/jama.290.16.2159. View

Paulson D, Light K . Elevation of serum and ventricular norepinephrine content in the diabetic rat. Res Commun Chem Pathol Pharmacol. 1981; 33(3):559-62. View

. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352(9131):837-53. View

Gelber D, Pfeifer M, Dawson B, Schumer M . Cardiovascular autonomic nervous system tests: determination of normative values and effect of confounding variables. J Auton Nerv Syst. 1997; 62(1-2):40-4. DOI: 10.1016/s0165-1838(96)00107-5. View

Gaede P, Vedel P, Larsen N, Jensen G, Parving H, Pedersen O . Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003; 348(5):383-93. DOI: 10.1056/NEJMoa021778. View

Low P, Denq J, Opfer-Gehrking T, Dyck P, OBrien P, Slezak J . Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects. Muscle Nerve. 1997; 20(12):1561-8. DOI: 10.1002/(sici)1097-4598(199712)20:12<1561::aid-mus11>3.0.co;2-3. View

Raffel D, Wieland D . Assessment of cardiac sympathetic nerve integrity with positron emission tomography. Nucl Med Biol. 2001; 28(5):541-59. DOI: 10.1016/s0969-8051(01)00210-4. View

Pop-Busui R, Kirkwood I, Schmid H, Marinescu V, Schroeder J, Larkin D . Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction. J Am Coll Cardiol. 2004; 44(12):2368-74. DOI: 10.1016/j.jacc.2004.09.033. View

10.

. The effect of intensive diabetes therapy on measures of autonomic nervous system function in the Diabetes Control and Complications Trial (DCCT). Diabetologia. 1998; 41(4):416-23. PMC: 2635092. DOI: 10.1007/s001250050924. View

11.

Stella P, Ellis D, Maser R, Orchard T . Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes. Incidence and predictors. J Diabetes Complications. 2000; 14(1):1-6. DOI: 10.1016/s1056-8727(00)00054-4. View

12.

Caldwell J, Link J, Levy W, Poole J, Stratton J . Evidence for pre- to postsynaptic mismatch of the cardiac sympathetic nervous system in ischemic congestive heart failure. J Nucl Med. 2008; 49(2):234-41. DOI: 10.2967/jnumed.107.044339. View

13.

Furlan R, Guzzetti S, Crivellaro W, Dassi S, Tinelli M, Baselli G . Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation. 1990; 81(2):537-47. DOI: 10.1161/01.cir.81.2.537. View

14.

Nathan D, Genuth S, Lachin J, Cleary P, Crofford O, Davis M . The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329(14):977-86. DOI: 10.1056/NEJM199309303291401. View

15.

Singer W, Sandroni P, Opfer-Gehrking T, Suarez G, Klein C, Hines S . Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol. 2006; 63(4):513-8. DOI: 10.1001/archneur.63.4.noc50340. View

16.

Spallone V, Bernardi L, Ricordi L, Solda P, Maiello M, CALCIATI A . Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. Diabetes. 1993; 42(12):1745-52. DOI: 10.2337/diab.42.12.1745. View

17.

Kennedy W, Navarro X, Sutherland D . Neuropathy profile of diabetic patients in a pancreas transplantation program. Neurology. 1995; 45(4):773-80. DOI: 10.1212/wnl.45.4.773. View

18.

Maser R, Mitchell B, Vinik A, Freeman R . The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care. 2003; 26(6):1895-901. DOI: 10.2337/diacare.26.6.1895. View

19.

Ziegler D, Dannehl K, Muhlen H, Spuler M, Gries F . Prevalence of cardiovascular autonomic dysfunction assessed by spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses at various stages of diabetic neuropathy. Diabet Med. 1992; 9(9):806-14. DOI: 10.1111/j.1464-5491.1992.tb01898.x. View

20.

Ewing D, Campbell I, CLARKE B . Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med. 1980; 92(2 Pt 2):308-11. DOI: 10.7326/0003-4819-92-2-308. View