Blood Flow Controls Coagulation Onset Via the Positive Feedback of Factor VII Activation by Factor Xa

Overview

Journal BMC Syst Biol

Publisher Biomed Central

Specialty Biology

Date 2010 Jan 28

PMID 20102623

Citations 16

Authors

Alexey M Shibeko

Ekaterina S Lobanova

Mikhail A Panteleev

Fazoil I Ataullakhanov

Affiliations

Soon will be listed here.

Abstract

Background: Blood coagulation is a complex network of biochemical reactions, which is peculiar in that it is time- and space-dependent, and has to function in the presence of rapid flow. Recent experimental reports suggest that flow plays a significant role in its regulation. The objective of this study was to use systems biology techniques to investigate this regulation and to identify mechanisms creating a flow-dependent switch in the coagulation onset.

Results: Using a detailed mechanism-driven model of tissue factor (TF)-initiated thrombus formation in a two-dimensional channel we demonstrate that blood flow can regulate clotting onset in the model in a threshold-like manner, in agreement with existing experimental evidence. Sensitivity analysis reveals that this is achieved due to a combination of the positive feedback of TF-bound factor VII activation by activated factor X (Xa) and effective removal of factor Xa by flow from the activating patch depriving the feedback of "ignition". The level of this trigger (i.e. coagulation sensitivity to flow) is controlled by the activity of tissue factor pathway inhibitor.

Conclusions: This mechanism explains the difference between red and white thrombi observed in vivo at different shear rates. It can be speculated that this is a special switch protecting vascular system from uncontrolled formation and spreading of active coagulation factors in vessels with rapidly flowing blood.

Citing Articles

A new look at TFPI inhibition of factor X activation.

Santiago F, Kaur A, Bride S, Monroe D, Leiderman K, Sindi S PLoS Comput Biol. 2024; 20(11):e1012509.

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Kumano O, Suzuki S, Yamazaki M, An Y, Yasaka M, Ieko M Int J Hematol. 2024; 119(4):407-415.

PMID: 38334914 DOI: 10.1007/s12185-024-03712-4.

Chemical Adjustment of Fibrinolysis.

Shibeko A, Ilin I, Podoplelova N, Sulimov V, Panteleev M Pharmaceuticals (Basel). 2024; 17(1).

PMID: 38256925 PMC: 10819531. DOI: 10.3390/ph17010092.

A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability.

Chung D, Bakshi S, van der Graaf P Pharmaceutics. 2023; 15(3).

PMID: 36986779 PMC: 10054658. DOI: 10.3390/pharmaceutics15030918.

Inhibition of platelet-surface-bound proteins during coagulation under flow I: TFPI.

Miyazawa K, Fogelson A, Leiderman K Biophys J. 2022; 122(1):99-113.

PMID: 36403087 PMC: 9822800. DOI: 10.1016/j.bpj.2022.11.023.

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