Poly(A)-binding Protein (PABP): a Common Viral Target

Overview

Journal Biochem J

Specialty Biochemistry

Date 2010 Jan 28

PMID 20102337

Citations 48

Authors

Richard W P Smith

Nicola K Gray

Affiliations

Soon will be listed here.

Abstract

Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

Citing Articles

HPV and RNA Binding Proteins: What We Know and What Remains to Be Discovered.

Graham S Viruses. 2024; 16(5).

PMID: 38793664 PMC: 11126060. DOI: 10.3390/v16050783.

PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment.

Zhang Q, Ye H, Liu C, Zhou H, He M, Liang X Virol Sin. 2023; 39(2):235-250.

PMID: 38072230 PMC: 11074649. DOI: 10.1016/j.virs.2023.12.001.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.

Mihalic F, Simonetti L, Giudice G, Rubin Sander M, Lindqvist R, Peters M Nat Commun. 2023; 14(1):2409.

PMID: 37100772 PMC: 10132805. DOI: 10.1038/s41467-023-38015-5.

Diverse yeast antiviral systems prevent lethal pathogenesis caused by the L-A mycovirus.

Chau S, Gao J, Diao A, Cao S, Azhieh A, Davidson A Proc Natl Acad Sci U S A. 2023; 120(11):e2208695120.

PMID: 36888656 PMC: 10089162. DOI: 10.1073/pnas.2208695120.

The game between host antiviral innate immunity and immune evasion strategies of senecavirus A - A cell biological perspective.

Zhao K, Zhang S, Liu X, Guo X, Guo Z, Zhang X Front Immunol. 2023; 13:1107173.

PMID: 36618383 PMC: 9813683. DOI: 10.3389/fimmu.2022.1107173.