Bone Mineral Density and Prevalent Osteoarthritis of the Hip in Older Men for the Osteoporotic Fractures in Men (MrOS) Study Group

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2010 Jan 27

PMID 20101493

Citations 39

Authors

R K Chaganti

N Parimi

T Lang

E Orwoll

M L Stefanick

M Nevitt

N E Lane

Affiliations

Soon will be listed here.

Abstract

Summary: We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA.

Introduction: We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men.

Methods: A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age > or = 65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates.

Results: Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7-10.0% difference; p value 0.0012 and p value < 0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not.

Conclusion: Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.

Citing Articles

Causal association between bone mineral density and the risk of joint replacement in patients with osteoarthritis: a Mendelian randomization study.

Zhu R, Xing X, Bian J, Zhang X, Ge L, Cai G Clin Rheumatol. 2024; 44(2):823-830.

PMID: 39738847 DOI: 10.1007/s10067-024-07289-5.

Arthritis Foundation/HSS Workshop on Hip Osteoarthritis, Part 1: Epidemiology, Early Development, and Cohorts From Around the World.

Kim J, Agricola R, Kim Y, Lane N, Millis M, Nelson A HSS J. 2023; 19(4):395-401.

PMID: 37937080 PMC: 10626936. DOI: 10.1177/15563316231189748.

Correlation between Bone Mineral Density and Progression of Hip Osteoarthritis in Adult Men and Women in Bulgaria-Results from a 7-Year Study.

Sapundzhiev L, Sapundzhieva T, Mitev M, Simitchiev K, Batalov A Life (Basel). 2023; 13(2).

PMID: 36836778 PMC: 9961715. DOI: 10.3390/life13020421.

Causal relationship between osteoporosis and osteoarthritis: A two-sample Mendelian randomized study.

Lin L, Luo P, Yang M, Wang J, Hou W, Xu P Front Endocrinol (Lausanne). 2022; 13:1011246.

PMID: 36339427 PMC: 9633945. DOI: 10.3389/fendo.2022.1011246.

Hip structure analysis and femoral osteodensitometry in aged postmenopausal women with hip osteoarthritis and femoral neck fracture.

Jadzic J, Zagorac S, Djuric M, Djonic D Int Orthop. 2022; 46(12):2747-2755.

PMID: 36222881 DOI: 10.1007/s00264-022-05602-y.

References

Lane N, Nevitt M, Genant H, Hochberg M . Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar disc degeneration. J Rheumatol. 1993; 20(11):1911-8. View

DellAccio F, De Bari C, El Tawil N, Barone F, Mitsiadis T, ODowd J . Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Res Ther. 2006; 8(5):R139. PMC: 1779445. DOI: 10.1186/ar2029. View

Bergink A, Uitterlinden A, van Leeuwen J, Hofman A, Verhaar J, Pols H . Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study. Bone. 2005; 37(4):446-56. DOI: 10.1016/j.bone.2005.05.001. View

Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A . Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res. 2004; 19(6):1006-12. DOI: 10.1359/JBMR.040307. View

Radin E, Paul I, Rose R . Role of mechanical factors in pathogenesis of primary osteoarthritis. Lancet. 1972; 1(7749):519-22. DOI: 10.1016/s0140-6736(72)90179-1. View

Washburn R, Smith K, Jette A, Janney C . The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993; 46(2):153-62. DOI: 10.1016/0895-4356(93)90053-4. View

Layton M, Goldstein S, Goulet R, Feldkamp L, Kubinski D, BOLE G . Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography. Arthritis Rheum. 1988; 31(11):1400-5. DOI: 10.1002/art.1780311109. View

Verbrugge L, Patrick D . Seven chronic conditions: their impact on US adults' activity levels and use of medical services. Am J Public Health. 1995; 85(2):173-82. PMC: 1615320. DOI: 10.2105/ajph.85.2.173. View

Lane N, Nevitt M, Lui L, de Leon P, Corr M . Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum. 2007; 56(10):3319-25. DOI: 10.1002/art.22867. View

10.

Croft P, Cooper C, Wickham C, Coggon D . Defining osteoarthritis of the hip for epidemiologic studies. Am J Epidemiol. 1990; 132(3):514-22. DOI: 10.1093/oxfordjournals.aje.a115687. View

11.

Chappard C, Peyrin F, Bonnassie A, Lemineur G, Brunet-Imbault B, Lespessailles E . Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study. Osteoarthritis Cartilage. 2006; 14(3):215-23. DOI: 10.1016/j.joca.2005.09.008. View

12.

Lian K, Lang T, Keyak J, Modin G, Rehman Q, Do L . Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int. 2004; 16(6):642-50. DOI: 10.1007/s00198-004-1736-9. View

13.

Marshall L, Lang T, Lambert L, Zmuda J, Ensrud K, Orwoll E . Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res. 2006; 21(8):1197-206. DOI: 10.1359/jbmr.060506. View

14.

Carlson C, Loeser R, Jayo M, WEAVER D, Adams M, Jerome C . Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease. J Orthop Res. 1994; 12(3):331-9. DOI: 10.1002/jor.1100120305. View

15.

Fazzalari N, Moore R, Manthey B, Vernon-Roberts B . Comparative study of iliac crest and subchondral femoral bone in osteoarthritic patients. Bone. 1992; 13(4):331-5. DOI: 10.1016/8756-3282(92)90079-c. View

16.

Mansell J, Collins C, Bailey A . Bone, not cartilage, should be the major focus in osteoarthritis. Nat Clin Pract Rheumatol. 2007; 3(6):306-7. DOI: 10.1038/ncprheum0505. View

17.

Genant H, Block J, Steiger P, Glueer C, Smith R . Quantitative computed tomography in assessment of osteoporosis. Semin Nucl Med. 1987; 17(4):316-33. DOI: 10.1016/s0001-2998(87)80024-7. View

18.

Hochberg M, Lethbridge-Cejku M, Tobin J . Bone mineral density and osteoarthritis: data from the Baltimore Longitudinal Study of Aging. Osteoarthritis Cartilage. 2003; 12 Suppl A:S45-8. DOI: 10.1016/j.joca.2003.09.008. View

19.

Zhang Y, Hannan M, Chaisson C, McAlindon T, Evans S, Aliabadi P . Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol. 2000; 27(4):1032-7. View

20.

Burger H, van Daele P, Odding E, VALKENBURG H, Hofman A, Grobbee D . Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The Rotterdam Study. Arthritis Rheum. 1996; 39(1):81-6. DOI: 10.1002/art.1780390111. View