Fibroblast Growth Factor Signalling: from Development to Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2010 Jan 23

PMID 20094046

Citations 1249

Authors

Nicholas Turner

Richard Grose

Affiliations

Soon will be listed here.

Abstract

Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular proliferation, survival, migration and differentiation. Although targeting FGF signalling as a cancer therapeutic target has lagged behind that of other receptor tyrosine kinases, there is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed. Although FGF signalling can drive tumorigenesis, in different contexts FGF signalling can mediate tumour protective functions; the identification of the mechanisms that underlie these differential effects will be important to understand how FGF signalling can be most appropriately therapeutically targeted.

Citing Articles

Development and Characterization of Three Novel FGFR Inhibitor Resistant Cervical Cancer Cell Lines to Help Drive Cervical Cancer Research.

Bou Antoun N, Afshan Mahmood H, Walker A, Modjtahedi H, Grose R, Chioni A Int J Mol Sci. 2025; 26(5).

PMID: 40076427 PMC: 11898767. DOI: 10.3390/ijms26051799.

Recent Advances in Succinate Dehydrogenase Deficient Gastrointestinal Stromal Tumor Systemic Therapies.

Dedousis D, Gadra E, Van Galen J, von Meren M Curr Treat Options Oncol. 2025; .

PMID: 40045030 DOI: 10.1007/s11864-025-01304-w.

Single-cell Analysis Highlights Anti-apoptotic Subpopulation Promoting Malignant Progression and Predicting Prognosis in Bladder Cancer.

Chen L, Hao Y, Zhai T, Yang F, Chen S, Lin X Cancer Inform. 2025; 24:11769351251323569.

PMID: 40018511 PMC: 11866393. DOI: 10.1177/11769351251323569.

A Comprehensive Review of Current Approaches in Bladder Cancer Treatment.

Kumbham S, Md Mahabubur Rahman K, Foster B, You Y ACS Pharmacol Transl Sci. 2025; 8(2):286-307.

PMID: 39974639 PMC: 11833730. DOI: 10.1021/acsptsci.4c00663.

Deep immune profiling of intrahepatic cholangiocarcinoma with CODEX multiplexed imaging.

Baretti M, Shekhar S, Sahai V, Shu D, Howe K, Gunchick V Hepatol Commun. 2025; 9(3).

PMID: 39969434 PMC: 11841852. DOI: 10.1097/HC9.0000000000000632.

References

Poon R, Fan S, Wong J . Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol. 2001; 19(4):1207-25. DOI: 10.1200/JCO.2001.19.4.1207. View

Zhao Y, Zhang Z . The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3. J Biol Chem. 2001; 276(34):32382-91. DOI: 10.1074/jbc.M103369200. View

Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A . FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res. 2008; 68(7):2340-8. DOI: 10.1158/0008-5472.CAN-07-5229. View

Wiedemann M, Trueb B . Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics. 2000; 69(2):275-9. DOI: 10.1006/geno.2000.6332. View

Zhang X, Ibrahimi O, Olsen S, Umemori H, Mohammadi M, Ornitz D . Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006; 281(23):15694-700. PMC: 2080618. DOI: 10.1074/jbc.M601252200. View

Ornitz D, Itoh N . Fibroblast growth factors. Genome Biol. 2001; 2(3):REVIEWS3005. PMC: 138918. DOI: 10.1186/gb-2001-2-3-reviews3005. View

Simon R, Richter J, Wagner U, Fijan A, Bruderer J, Schmid U . High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer. Cancer Res. 2001; 61(11):4514-9. View

Nord H, Segersten U, Sandgren J, Wester K, Busch C, Menzel U . Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma. Int J Cancer. 2009; 126(6):1390-402. DOI: 10.1002/ijc.24954. View

Dillon C, Spencer-Dene B, Dickson C . A crucial role for fibroblast growth factor signaling in embryonic mammary gland development. J Mammary Gland Biol Neoplasia. 2004; 9(2):207-15. DOI: 10.1023/B:JOMG.0000037163.56461.1e. View

10.

Avet-Loiseau H, Li J, Facon T, Brigaudeau C, Morineau N, Maloisel F . High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies. Cancer Res. 1998; 58(24):5640-5. View

11.

Greenman C, Stephens P, Smith R, Dalgliesh G, Hunter C, Bignell G . Patterns of somatic mutation in human cancer genomes. Nature. 2007; 446(7132):153-8. PMC: 2712719. DOI: 10.1038/nature05610. View

12.

Peters K, Marie J, Wilson E, IVES H, Escobedo J, del Rosario M . Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis. Nature. 1992; 358(6388):678-81. DOI: 10.1038/358678a0. View

13.

Memarzadeh S, Xin L, Mulholland D, Mansukhani A, Wu H, Teitell M . Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 2007; 12(6):572-85. PMC: 2931420. DOI: 10.1016/j.ccr.2007.11.002. View

14.

Ricol D, Cappellen D, el Marjou A, Gil-Diez-de-Medina S, Girault J, Yoshida T . Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer. Oncogene. 1999; 18(51):7234-43. DOI: 10.1038/sj.onc.1203186. View

15.

Giri D, Ropiquet F, Ittmann M . Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer. Clin Cancer Res. 1999; 5(5):1063-71. View

16.

Meyer K, Maia A, OReilly M, Teschendorff A, Chin S, Caldas C . Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol. 2008; 6(5):e108. PMC: 2365982. DOI: 10.1371/journal.pbio.0060108. View

17.

Reis-Filho J, Simpson P, Turner N, Lambros M, Jones C, Mackay A . FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res. 2006; 12(22):6652-62. DOI: 10.1158/1078-0432.CCR-06-1164. View

18.

Jackson D, Bresnick J, Rosewell I, Crafton T, Poulsom R, Stamp G . Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland. J Cell Sci. 1997; 110 ( Pt 11):1261-8. DOI: 10.1242/jcs.110.11.1261. View

19.

Jang J, Shin K, Park J . Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res. 2001; 61(9):3541-3. View

20.

Aman A, Piotrowski T . Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Dev Cell. 2008; 15(5):749-61. DOI: 10.1016/j.devcel.2008.10.002. View